I didn't know I was a diversity pioneer by entering this field that is the 2nd least diverse specialty in medicine. Finasteride and dutasteride, which were developed as 5-α reductase inhibitors, have been approved by the FDA and are being used as the main treatments for AGA. For the development of AGA treatment using AR68, AR68 (Cosmerna-68) is listed as a cosmetic ingredient in cosmetic ingredients (ICID) and the Cosmetic Ingredient Dictionary, which are reviewed by the PCPC (Personal Care Products Council) and KCA (Korea Cosmetic Association), respectively.

Fourteen SAMiRNA candidates were selected based on their knockdown efficiency (> 50% AR silencing efficacy) (Supplementary Fig. This study demonstrates that inhibiting AR expression using SAMiRNA nanoparticles targeting human AR mRNA is an effective method for AGA treatment.The following primer sets were used: AR, forward 5′-TTGTACACGTGGTCAAGTGG-3′ and reverse 5′-TGGAGTTGACATTGGTGAAGG-3′; RPLPO, forward 5′-TGCCATTGCCCCATGTGAAG-3′ and reverse 5′-AGCTGCACATCACTCAGGATT-3′; IL-1B, forward 5′-CTGAGCTCGCCAGTGAAAT-3′ and reverse 5′-CTGTAGTGGTGGTCGGAGA-3′; IL-6, forward 5′-AGATGCAATAACCACCCCTG-3′ and reverse 5′-TGCGCAGAATGAGATGAGTT-3′; TNF, forward 5′-CTGTAGCCCATGTTGTAGCA-3′ and reverse 5′-GGTTATCTCTCAGCTCCACG-3′; IFNG, forward 5′-GAATGTCCAACGCAAAGCAA-3′ and reverse 5′-ACCTCGAAACAGCATCTGAC-3′; RPL13A, forward 5′-TGCCATTGCCCCATGTGAAG-3′ and reverse 5′-AGCTGCACATCACTCAGGATT-3′; IL-1B, forward 5′-GTGTTTGACGGCATCCCACC-3′ and reverse 5′-TAGGCTTCAGACGCACGACC-3′. It improves hair loss from Androgenetic Alopecia in men and women by strengthening the hair follicle, resulting in thicker, fuller, and healthier hair. The intensity of the AR and GAPDH bands was quantified by ImageJ software, and AR protein expression was normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) values ( c, lower panel). This is quite extraordinary for a new cosmeceutical hair loss product that will only be sold in one region (Western Europe) for the time being. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material.

AR68 treatment significantly reduced the AR mRNA and protein levels in HFDPCs and human hair follicles. After first being done in South Korea, CosmeRNA’s safety study was repeated in Europe by Dermatest in 2022. Laser light therapy utilizes light in wavelengths ranging from red to infrared to stimulate tissue regeneration and repair. Honestly, some of his comments are suspiciously wrong to me, especially if he really holds a PhD in biochemistry or molecular biology. In the high-dose AR68 group, the total hair count increased significantly at 24 weeks compared to that at the baseline (4.Particle counts (≥ 50 events each) were finally determined using the qNano software provided by Izon Science (Izon Control Suite Version 3. We had an unconventional route to commercialization by developing a hair loss cosmeceutical product. This microRNA could aid hair regrowth by softening hair follicles, which naturally become stiffer as we age and contribute to hair loss.

The AR68 hair tonic was packaged in a piston-type bottle with a silicon adaptor for massage (Supplementary Fig. Plucked human hair follicles were treated with 10 μM SAMiRNA-AR68 for 48 h followed by qPCR and immunofluorescence analysis. To calculate the overall star rating and percentage breakdown by star, we don’t use a simple average. Additionally, SAMiRNA nanoparticles do not show innate immune stimulation effects, unlike conventional siRNA formulations.The intensity of the AR and GAPDH bands was quantified by ImageJ software, and AR protein expression was normalized to GAPDH values ( b, right panel). All data are presented as the mean ± standard deviation (SD), and the number of samples is indicated in each figure legend.