Cocaine True, Cocaine Blue

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Cocaine True, Cocaine Blue

Cocaine True, Cocaine Blue

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Hummel M, Unterwald EM (April 2002). "D1 dopamine receptor: a putative neurochemical and behavioral link to cocaine action". Journal of Cellular Physiology. 191 (1): 17–27. doi: 10.1002/jcp.10078. PMID 11920678. S2CID 40444893. The biosynthesis begins with L- Glutamine, which is derived to L- ornithine in plants. The major contribution of L-ornithine and L- arginine as a precursor to the tropane ring was confirmed by Edward Leete. [139] Ornithine then undergoes a pyridoxal phosphate-dependent decarboxylation to form putrescine. In some animals, the urea cycle derives putrescine from ornithine. L-ornithine is converted to L-arginine, [140] which is then decarboxylated via PLP to form agmatine. Hydrolysis of the imine derives N-carbamoylputrescine followed with hydrolysis of the urea to form putrescine. The separate pathways of converting ornithine to putrescine in plants and animals have converged. A SAM-dependent N-methylation of putrescine gives the N-methylputrescine product, which then undergoes oxidative deamination by the action of diamine oxidase to yield the aminoaldehyde. Schiff base formation confirms the biosynthesis of the N-methyl-Δ 1-pyrrolinium cation. Benjamin E, Wong DK, Choa D (December 2004). " 'Moffett's' solution: a review of the evidence and scientific basis for the topical preparation of the nose". Clinical Otolaryngology and Allied Sciences. 29 (6): 582–587. doi: 10.1111/j.1365-2273.2004.00894.x. PMID 15533141. Connors NJ, Hoffman RS (November 2013). "Experimental treatments for cocaine toxicity: a difficult transition to the bedside". The Journal of Pharmacology and Experimental Therapeutics. 347 (2): 251–7. doi: 10.1124/jpet.113.206383. PMID 23978563. S2CID 6767268.

When the Spanish arrived in South America, the conquistadors at first banned coca as an "evil agent of devil". But after discovering that without the coca the locals were barely able to work, the conquistadors legalized and taxed the leaf, taking 10% off the value of each crop. [159] In 1569, Spanish botanist Nicolás Monardes described the indigenous peoples' practice of chewing a mixture of tobacco and coca leaves to induce "great contentment": Boswell HD, Dräger B, McLauchlan WR, Portsteffen A, Robins DJ, Robins RJ, Walton NJ (November 1999). "Specificities of the enzymes of N-alkyltropane biosynthesis in Brugmansia and Datura". Phytochemistry. 52 (5): 871–8. Bibcode: 1999PChem..52..871B. doi: 10.1016/S0031-9422(99)00293-9. PMID 10626376.Alvarenga TA, Andersen ML, Ribeiro DA, Araujo P, Hirotsu C, Costa JL, Battisti MC, Tufik S (January 2010). "Single exposure to cocaine or ecstasy induces DNA damage in brain and other organs of mice". Addiction Biology. 15 (1): 96–9. doi: 10.1111/j.1369-1600.2009.00179.x. PMID 19878142. S2CID 21347765. Lluch J, Rodríguez-Arias M, Aguilar MA, Miñarro J (November 2005). "Role of dopamine and glutamate receptors in cocaine-induced social effects in isolated and grouped male OF1 mice". Pharmacology Biochemistry and Behavior. 82 (3): 478–87. doi: 10.1016/j.pbb.2005.10.003. PMID 16313950. S2CID 13307446.

When they wished to make themselves drunk and out of judgment they chewed a mixture of tobacco and coca leaves which make them go as they were out of their wittes. [160] Mieczkowski, Tom (25 November 2020). Drug Testing Technology: Assessment of Field Applications. CRC Press. p.124. ISBN 978-1-000-14222-8. Pure cocaine is a crystalline powder derived from the leaves of the coca plant. It is uncut and unadulterated by other substances.Sordo L, Indave BI, Barrio G, Degenhardt L, de la Fuente L, Bravo MJ (September 2014). "Cocaine use and risk of stroke: a systematic review". Drug and Alcohol Dependence. 142: 1–13. doi: 10.1016/j.drugalcdep.2014.06.041. PMID 25066468. Cocaine may be detected by law enforcement using the Scott reagent. The test can easily generate false positives for common substances and must be confirmed with a laboratory test. [146] [147] Sigma Receptors Play Role in Cocaine-induced Suppression of Immune System". Sciencedaily.com. 6 May 2003. Archived from the original on 12 January 2011 . Retrieved 9 March 2010.

Nutt D, King LA, Saulsbury W, Blakemore C (March 2007). "Development of a rational scale to assess the harm of drugs of potential misuse". Lancet. 369 (9566): 1047–53. doi: 10.1016/S0140-6736(07)60464-4. PMID 17382831. S2CID 5903121. Depending on liver and kidney function, cocaine metabolites are detectable in urine. Benzoylecgonine can be detected in urine within four hours after cocaine intake and remains detectable in concentrations greater than 150ng/mL typically for up to eight days after cocaine is used. Detection of cocaine metabolites in hair is possible in regular users until after the sections of hair grown during the period of cocaine use are cut or fall out. [104] Pharmacodynamics a b c "Goprelto – cocaine hydrochloride solution". DailyMed. 3 January 2020 . Retrieved 30 April 2020.Meet the Chemist Behind Many Popular—and Faulty—Police Drug Kits". Pacific Standard. 22 June 2016 . Retrieved 21 April 2020.



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