Savlon Scar Prevention Gel 50g, First Aid Treatment to Help Soothe Minor Wounds and Burns and Reduce Likelihood of Scarring (Pack of 1, Packaging May Vary)

£7.495
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Savlon Scar Prevention Gel 50g, First Aid Treatment to Help Soothe Minor Wounds and Burns and Reduce Likelihood of Scarring (Pack of 1, Packaging May Vary)

Savlon Scar Prevention Gel 50g, First Aid Treatment to Help Soothe Minor Wounds and Burns and Reduce Likelihood of Scarring (Pack of 1, Packaging May Vary)

RRP: £14.99
Price: £7.495
£7.495 FREE Shipping

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The researchers are conducting more tests to further refine the magnetic wound-healing gel to improve its effectiveness. They are also collaborating with a clinical partner to test the effectiveness of the gel using diabetic human tissues.

Angiogenesis is another important event in burn healing where endothelial cells’ proliferation rate in the wound area is rapidly increased after burning to form blood vessels. Hamid and Soliman (2015) reported that AV can increase angiogenesis [ 2] for a better supply with nutrients and oxygen because of acemannan in AV [ 57]. Histologically, AM, AV and AM+AV treated wounds had increased numbers of blood vessels, particularly small and newly formed (Fig. ​ (Fig.6a17-a19, 6a17-a19, 6d). Besides supporting in vitro keratinocyte proliferation, we also observed some proliferating basal keratinocytes in vivo residing in the intermediate zone of the epidermis and dermis (Fig. ​ (Fig.6a19). 6a19). These properties of the tested gels could be explained by the presence of stimulatory factors in amniotic membrane which also been supported from the results of Murphy et al. (2017) [ 24]. The proliferative phase is characterized by the formation of granulation tissue, reepithelialization, and neovascularization. This phase can last several weeks.Wound healing, especially in the field of diabetic foot ulcers, has always been a challenging arena. Diabetic foot patients do not heal as well as normal patients and their healing journey is often prolonged,” said Assistant Professor Francis Wong Keng Lin, Consultant,Department of Orthopaedic Surgery, Sengkang General Hospital. The inflammatory phase begins with hemostasis and chemotaxis. Both the white cells and thrombocytes speed up the inflammatory process by releasing more mediators and cytokines. Besides the platelet-derived growth factor, other factors promote collagen degradation, the transformation of fibroblasts, the growth of new vessels, and re-epithelialization. All of the processes occur at the same time but in a synchronized fashion. Mediators like serotonin and histamine are released from platelets and increase cellular permeability. The platelet-derived growth factor attracts fibroblasts and, along with transforming growth factor, enhances the division and multiplication of fibroblasts. The fibroblasts, in turn, synthesize collagen.

Assistant Professor Francis Wong Keng Lin, a Consultant at the Department of Orthopaedic Surgery at Sengkang General Hospital, added: “Wound healing, especially in the field of diabetic foot ulcers, has always been a challenging arena. Diabetic foot patients do not heal as well as normal patients and their healing journey is often prolonged.”

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The team of researchers are furthering their research to finetune the effectiveness of the magnetic wound-healing gel and are testing the gel’s effectiveness on the tissue of people with diabetes.

Neutrophil cell infiltration expedited hydrogel degradation, which lead to vascular cell infiltration. Over half a billion people across the world are currently living with diabetes, and this number continues to increase. Therefore, chronic diabetic wounds are becoming a “global healthcare challenge”. Increase the oxygen concentration in blood in the wound area and shortens the wound healing processBioadhesive hydrogels facilitate the adhesion of a hydrogel dressing to a wet wound bed and can provide long-term stability. Due to their flexibility and stretchability, the presence of a hydrogel on the wound provides comfort to the patient. Compared to conventional wound dressings, such as gauze and films, bioadhesive hydrogels are biologically more compatible and can be removed more easily from the wound. The bioadhesive property can be provided to the hydrogel dressings by modification with polyphenol derived moieties, such as catechol, dopamine, gallic acid, or tannic acid [ 51, 52, 58, 79, 80]. There are hydrogels that possess intrinsic antibacterial properties. Chitosan, for example, is known to have inherent antibacterial activity. The electrostatic interaction between its polycationic structures with the negatively charged bacterial cell wall alters membrane permeability [ 92]. Upon destruction of the bacterial cell wall, the subsequent interaction of the chitosan with the bacterial intracellular components inhibits DNA replication. According to researchers from the National University of Singapore (NUS), “chronic diabetic wounds are a significant global healthcare challenge”.



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