Handbook of pharmaceutical excipients: 6th Revised edition
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Handbook of pharmaceutical excipients: 6th Revised edition
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You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer Acacia storage conditions, pH, and the presence of salts. Viscosity increases slowly up to about 25% w/v concentration and exhibits Newtonian behavior. Above this concentration, viscosity increases rapidly (non-Newtonian rheology). Increasing temperature or prolonged heating of solutions results in a decrease of viscosity owing to depolymerization or particle agglomeration. See also Section 12. Acacia is incompatible with a number of substances including amidopyrine, apomorphine, cresol, ethanol (95%), ferric salts, morphine, phenol, physostigmine, tannins, thymol, and vanillin. An oxidizing enzyme present in acacia may affect preparations containing easily oxidizable substances. However, the enzyme may be inactivated by heating at 1008C for a short time; see Section 11. Many salts reduce the viscosity of aqueous acacia solutions, while trivalent salts may initiate coagulation. Aqueous solutions carry a negative charge and will form coacervates with gelatin and other substances. In the preparation of emulsions, solutions of acacia are incompatible with soaps. 13
Included in the FDA Inactive Ingredients Guide (inhalation solution; oral tablets; topical preparations). Included in the Canadian List of Acceptable Non-medicinal Ingredients. Included in nonparenteral medicines licensed in the UK. 17
Acetone reacts violently with oxidizing agents, chlorinated solvents, and alkali mixtures. It reacts vigorously with sulfur dichloride, potassium t-butoxide, and hexachloromelamine. Acetone should not be used as a solvent for iodine, as it forms a volatile compound that is extremely irritating to the eyes.(4) 13 Length 1 angstrom (a˜) = 10–10 meter (m) 1 inch (in) = 2.54 10–2 meter (m) 1 foot (ft) = 3.048 10–1 meter (m) 1 yard (yd) = 9.144 10–1 meter (m) Acesulfame potassium possesses good stability. In the bulk form it shows no sign of decomposition at ambient temperature over many years. In aqueous solutions (pH 3.0–3.5 at 208C) no reduction in sweetness was observed over a period of approximately 2 years. Stability at elevated temperatures is good, although some decomposition was noted following storage at 408C for several months. Sterilization and pasteurization do not affect the taste of acesulfame potassium.(5) The bulk material should be stored in a well-closed container in a cool, dry place. 12
Sugar (sucrose) has now been replaced by film coating using natural or synthetic polymers. Polymers that are insoluble in acid, e.g. cellulose acetate phthalate, are used for enteric coatings to delay release of the active ingredient. A specification for acetone is included in the Japanese Pharmaceutical Excipients (JPE).(7) The EINECS number for acetone is 200-662-2. Handbook of Pharmaceutical Excipients, 9th edition is now available. But it need to buy from pharmpress.com. But previous (6th, 7th, 8th) edition of Handbook of Pharmaceutical Excipients are available online with pdf format. Fortunately, pharma specialists will provide you a comprehensive knowledge about the book of pharmaceutical excipients. And we hope it will be a best summary of Handbook of Pharmaceutical Excipients.Agar-agar; Bengal isinglass; Ceylon isinglass; Chinese isinglass; E406; gelosa; gelose; Japan agar; Japan isinglass; layor carang. 3 Bhardwaj TJ, Kanwar M, Lal R, Gupta A. Natural gums and modified natural gums as sustained release carriers. Drug Dev Ind Pharm 2000; 26(10): 1025–1038. 2 Sakr FM, El-Said Y, El-Helw A. Design and evaluation of a dry solidification technique for preparing pharmaceutical beads. STP Pharma Sci 1995; 5(4): 291–295. 3 Boraie NA, Naggar VF. Sustained release of theophylline and aminophylline from agar tablets. Acta Pharm Jugosl 1984; 34(Oct–Dec): 247–256. 4 Nakano M, Nakamura Y, Takikawa K, et al. Sustained release of sulfamethizole from agar beads. J Pharm Pharmacol 1979; 31: 869–872. 5 Fassihi AR. Characteristics of hydrogel as disintegrant in solid dose technology. J Pharm Pharmacol 1989; 54: 59–62. 6 Desai S, Boston S. A floating controlled-release drug delivery system: in vitro–in vivo evaluation. Pharm Res 1993; 10: 1321– 1325. 7 Singh KK, Deshpande SG, Baichwal MR. Studies on suppository bases: design and evaluation of sodium CMC and agar bases. Indian Drugs 1994; 31(April): 149–154. 8 Kahela P, Hurmerinta T, Elfving R. Effect of suspending agents on the bioavailability of erythromycin ethylsuccinate mixtures. Drug Dev Ind Pharm 1978; 4(3): 261–274. 9 Gennaro AR, ed. Remington: The Science and Practice of Pharmacy, 20th edn. Baltimore: Lippincott Williams & Wilkins, 2000: 1030. 10 Lewis RJ, ed. Sax’s Dangerous Properties of Industrial Materials, 11th edn. New York: Wiley, 2004: 90–91.
All of the 400+ monographs are also thoroughly cross-referenced and indexed to allow their identification by chemical, non-proprietary or trade names. It is internationally recognised as the authoritative source of information on pharmaceutical excipients and a comprehensive guide to uses, properties and safety. Editorial Staff Editorial Staff of the Pharmaceutical Press: Laurent Y Galichet Louise ME McIndoe Siaˆn C Owen Paul J WellerProtect tablet from the environment (air, light and moisture), increase the mechanical strength, mask taste and smell, aid swallowing, assist in product identification. Can be used to modify release of the active ingredient. May contain flavours and colourings. Identification Characters Appearance of solution Acidity or alkalinity Relative density Related substances Matter insoluble in water Reducing substances Residue on evaporation Water Assay
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