focused their studies on 4,5,4’-trihydroxy-3,3’dimethoxybibenzyl (TDB) from Dendrobium ellipsophyllum and its anti-metastatic effect on lung cancer cells (H292) [ 28]. Since 2005, more than 320 patents have been registered, mostly Chinese, dealing with preparations containing Dendrobium plants for conditioning, regulating or alleviating cancer, diabetes or improve human immunity. Also, DF-A was shown to suppress EMT, as indicated by cadherin switch from N- to E-cadherin and decrease of Snail, Slug and vimentin, revealing thus the potential of DF-A as an anti-metastatic agent [ 44]. AChE and BChE inhibitory activities of isolated compounds were assayed using a spectrophotometric method.

Erianin, another promising bibenzyl was isolated from the stems of Dendrobium chrysotoxum, a plant used as an antipyretic and analgesic in TCM.How to Use-Use the dropper to absorb 1-2ml(measuring label in the dropperunder the tongue, 3 times a day. moscatilin) has been patented as an agent inhibiting cervical cancer cell proliferation and inducing autophagic apoptosis in vitro in an effective concentration in the range of 25-200 mol/L (patent CN105943523). Due to the high diversity of types of cancer, specific mechanisms of action have been explored to assign to Dendrobium spp. However, the wealth of molecular information now known about neurodegenerative diseases progression leads to questioning on the efficacy of developed treatments.

Immunomodulatory effects of DTP administered orally to Balb/c mice for 3 weeks were investigated and it was concluded oral administration of 100 mg/kg and 300 mg/kg of DTP led to a 16. Additional rats were treated by EDNLA thrice daily for one week, to examine the effects on LPS-induced apoptosis in the brain. revealed that denbinobin induces human glioblastoma multiforme (GBM) cell apoptosis through IκB kinase inactivation, followed by Akt and forkhead in rhabdomyosarcoma dephos-phorylation and caspase-3 activation signaling cascade.also demonstrated that chrysotoxine inhibits the neurotoxicity of 1-methyl-4-phenyl pyridinium (MPP +). Attenuation of 6-OHDA toxicity cells via mitochondria protection and NF-κB modulation Inhibition of the neurotoxicity of 1-methyl-4-phenyl pyridinium (MPP +). have been registered to be used as hypoglycemic drug for preventing and curing cardiovascular disease (patent CN103664568).