The AUC of omeprazole increases with repeated administration. This increase is dose-dependent and results in a non-linear dose-AUC relationship after repeated administration. This time- and dose-dependency is due to a decrease of first pass metabolism and systemic clearance probably caused by an inhibition of the CYP2C19 enzyme by omeprazole and/or its metabolites (e.g. the sulphone).

Omeprazole, given in doses of 40 mg to healthy subjects in a cross-over study, increased C max and AUC for cilostazol by 18% and 26% respectively, and one of its active metabolites by 29% and 69% respectively. Do not take Pyrocalm Control Tablets if you are taking a medicine containing nelfinavir (used to treat HIV infection). Omeprazole is acid labile and is therefore administered orally as enteric-coated tablets. Absorption of omeprazole is rapid, with peak plasma levels occurring approximately 1-2 hours after dose. Absorption of omeprazole takes place in the small intestine and is usually completed within 3-6 hours. Concomitant intake of food has no influence on the bioavailability. The systemic availability (bioavailability) from a single oral dose of omeprazole is approximately 40%. After repeated once-daily administration, the bioavailability increases to about 60%. Patients should consult their doctor before taking this medicinal product if they are due to have an endoscopy or urea breath test. Alopecia, photosensitivity, acute generalized exanthematous pustulosis (AGEP), drug reaction with eosinophilia and systemic symptoms (DRESS)Try to avoid fatty, spicy or acidic foods and specifically onions, chocolate, and gluten, as well as carbonated or caffeinated drinks.

For patients expected to be on prolonged treatment or who take PPIs with digoxin or drugs that may cause hypomagnesaemia (e.g., diuretics), healthcare professionals should consider measuring magnesium levels before starting PPI treatment and periodically during treatment. Increased Chromogranin A (CgA) level may interfere with investigations for neuroendocrine tumours. To avoid this interference, omeprazole treatment should be stopped for at least 5 days before CgA measurements (see section 5.1). If CgA and gastrin levels have not returned to reference range after initial measurement, measurements should be repeated 14 days after cessation of proton pump inhibitor treatment. Omeprazole is safe for use in adults and children over the age of 1 year. What is Omeprazole used for? Ketoconazole, itraconazole, posaconazole or voriconazole (used to treat infections caused by a fungus) Omeprazole tablets contain lactose. Patients with rare hereditary problems of galactose intolerance, the total lactase deficiency or glucose-galactose malabsorption should not take this medicine.Oral dosing with omeprazole 20 mg maintains an intragastric pH of ≥3 for a mean time of 17 hours of the 24-hour period in duodenal ulcer patients. The pharmacokinetics of omeprazole, including systemic bioavailability and elimination rate, are unchanged in patients with reduced renal function. When given together with proton-pump inhibitors, methotrexate levels have been reported to increase in some patients. In high-dose methotrexate administration a temporary withdrawal of omeprazole may need to be considered. Pyrocalm Control 20mg Gastro-Resistant Tablets are unsuitable for you if you’re allergic to Omeprazole, any of the other ingredients listed above, or any other proton pump inhibiting medicines (including lansoprazole, pantoprazole, esomeprazole or rabeprazole). Patients with long-term recurrent symptoms of indigestion or heartburn should see their doctor at regular intervals. Especially, patients over 55 years taking any 'over-the-counter' (OTC, non-prescription) indigestion or heartburn remedy on a daily basis should inform their pharmacist or doctor.