This supplement by NHV Natural Pet Products uses 100% natural milk thistle to support dogs through liver and kidney conditions in addition to conventional treatment by their veterinarian. Liver Support Benefits These are not the only studies involving SAMe, the other few papers (research and case reports) have previously been cited [ 13, 20, 23, 25]. 3.3. Phosphatidylcholine

FDA Registered Facility: Our manufacturing facility is FDA registered. Strict quality control procedures are meticulously monitored. Research has shown dogs with ascites (the accumulation of fluid in the peritoneal cavity) treated with silymarin along with supportive therapy were able to attain normal activities after 45 days of therapy indicating the effectiveness of silymarin on hepatic dysfunction ( 9). Ascites is most often caused by liver scarring such as in cirrhosis. Our main recommendation for conditions like diabetes is our Mellit supplement. The powerful yet gentle herbs found in Mellit can help to ease uncomfortable symptoms, manage blood sugar levels, and can improve energy and overall vitality. Denamarin may be recommended as part of a treatment plan for a variety of circumstances where the liver is involved. In cats, this can include conditions where liver enzymes are elevated on bloodwork like in cholangitis/cholangiohepatitis syndrome, hepatic lipidosis, and feline triad disease/triaditis. Milk thistle may also help the allergic cat. Since the liver produces histamine (an allergic reaction) when it is flooded with toxins, milk thistle can help decrease the histamines, thereby subduing the allergic response.

Denamarin for Cats Dosage

To assess the possible efficacy of nutraceuticals on liver diseases, studies on cell cultures have also been carried out on single molecules/complexes or on their combination, with not always concordant results. A recent study reports the effects of a pretreatment with the combination of S-adenosylmethionine and silybin on primary canine hepatocytes exposed to the proinflammatory cytokine IL-1 β, and these molecules are hypothesized as a possible support to the liver function. Indeed, the presence of this combination was associated with reduced levels of PGE 2, IL-8, and macrophage chemotactic protein-1 (proinflammatory molecules induced by IL-1 β administration) as well as to higher glutathione (GSH) levels (reduction of oxidative stress) [ 20]. Similarly, a previous study by the same authors reported the efficacy of silybin and of a silybin-phosphatidylcholine complex in canine primary hepatocyte cultures exposed to IL-1 β, as demonstrated by a significant reduction of proinflammatory markers (PGE 2, IL-8, and monocyte chemotactic protein-1) and by a decreased NF- κB nuclear translocation, for the silybin-phosphatidylcholine complex [ 22]. On the other hand, in a study on cultured canine hepatocytes, the exposition to silibinin and simultaneously to α-amanitin, a known liver toxin from amanitin containing mushrooms (e.g. Amanita phalloides), did not show protective effects on those cells, which are measured by hepatocytes viability and lactate dehydrogenase activity measurement [ 21]. 3.2. S-Adenosylmethionine (SAMe) Turmeric ( Curcuma longa) is a perennial herb member of the ginger family ( Zingiberaceae). It is well known for its uses as curry powder in Asian cuisine and yellow pigment in the food processing industry. From the powdered rhizome of turmeric, several curcuminoids have been extracted, but the most prominent is called curcumin [ 42]. Although still debated, traditionally, curcumin, that present a polyphenolic structure, has been used for its anticancer, antidiabetic, anti-inflammatory, antimicrobial, antioxidant, hepatoprotective, immunomodulatory, and renoprotective properties as reported in literature [ 42, 43]. 3.6. Taraxacum officinale, Dandelion An overdose of milk thistle can upset the stomach, cause diarrhea and gas. Discontinue the treatment if you notice any of these symptoms. These symptoms will subside once the dose is adjusted.

Full-Spectrum Extract: The full biochemical spectrum of the herbs is preserved to ensure the potency of the extract. All raw materials are tested for identification and purity.Milk Thistle is used today as an anticancer support. Studies are showing that Milk thistle extract has an effect against cancer. This could be because Milk Thistle has very good antioxidant properties, which act as free radical scavengers. Research is showing that it may in fact help reduce or slow down the grown of certain cancer cell, and may protect and prevent cells from dividing in your pet's body. Denamarin tablets are typically dosed once a day per the manufacturer’s advice. However, there are many reports that the most effective dosages for SAMe and silybin for certain conditions may need to be higher than the Denamarin label states. It's Guaranteed: In addition to the superior quality of our products, you are also protected by our Five-Star Experience or it's FREE. It is very interesting to notice that although only few research papers regarding the use of complementary feed to support liver function in dogs and cats are present in the literature, many different products are commercially available. Even though these few manuscripts are very interesting, following our search criteria, their reduced number as well as the number of subjects included do not provide strong evidence both in dogs and, especially, in cats. Furthermore, it must be considered that 4 out of 18 articles we found were case reports (Table 1). These kinds of papers do not fully meet the aim of our study because of their nature, and only Wallace et al. reported the use of a single “liver supporting molecule” (SAMe) [ 26] and not combinations as in others. Milk thistle does not have any side effects and is appropriate for long term use. Benefits of Milk Thistle for Cats

Cain terriers, Yorkshire terriers and Maltese are typical breeds of dogs that may show no outward clinical signs of liver disease but have elevated liver enzymes which may lead to portal hypertension over time. Some suggest supportive milk thistle therapy for this condition ( 5). SAMe is a natural compound made by cells throughout the body. It is an essential part of three major metabolism pathways that the liver uses. Supplements given to cats should not be extracted from alcohol as an alcohol-based tincture is unacceptable in taste, and buying products specifically for cats or pets in general is preferable. Dogs Milk Thistle is a natural, herbal supplement that is gentle enough for long-term use. Why choose Pet Wellbeing Milk Thistle for your feline friend? In conclusion, despite the wide presence of commercially available complementary feed to support liver function in dogs and cats and their widespread usage, studies on that topic (on molecules previously discussed) and on such species are rather scarce, while on the other hand, numerous studies have been carried out both in humans and in laboratory animals. Complementary feeds may represent a help in managing liver diseases in pets, but additional research studies are needed to confirm or exclude the presence of beneficial effects in different pathological conditions, including studies concerning the titration of active ingredients. Conflicts of Interest

Milk thistle

Milk thistle can help with some liver diseases, but not all. It has no side effects, so it's safe. Too much (more than a cat's system can handle) will cause loose stools or diarrhea. And under certain circumstances milk thistle can also cause vomiting.