Do not use if you have ever had an allergic reaction to Nurofen Plus or any of the ingredients listed at the end of the CMI. Side effects from codeine are theoretical warnings based on drug class. No clinical data is available to determine frequency. Ibuprofen is good for relieving period pain because it reduces the production of the prostaglandins that are involved in making the womb contract during your period. How do I take Nurofen? Nurofen Plus should be administered with caution in patients with hypertension or fluid retention (see Section 4.3 Contraindications, Heart).

These medicines may be affected by Nurofen Plus or may affect how well it works. You may need to take different amounts of your medicine, or you may need to take different medicines. Your doctor will advise you. Gastrointestinal bleeding, ulceration and perforation which can be fatal, has been reported with all NSAIDs at any time during treatment, with or without warning symptoms or a previous history of serious GI events.anti-blood-clotting (anticoagulant) medicines such as warfarin, dabigatran, apixaban, rivaroxaban, heparin and low molecular weight heparins such as enoxaparin If you're already taking any medicines, including those bought without a prescription and herbal medicines, you should always get advice from your pharmacist before taking Nurofen, to make sure the combination is safe. Nurofen Plus contains the active ingredients Ibuprofen and Codeine phosphate. Nurofen Plus is used to provide temporary relief of acute moderate pain and inflammation. For more information, see Section 1. Why am I using Nurofen Plus? in the full CMI. 2. What should I know before I use Nurofen Plus?

Depending on your body's individual ability to break down codeine, you may be getting reduced benefit or experience signs of overdose even when you take Nurofen Plus as recommended by your doctor. If overdose symptoms occur, seek immediate medical advice. If you use too much Nurofen Plus Hypotensive effects of antihypertensive agents may be potentiated when used concurrently with codeine and lead to orthostatic hypotension. NSAIDs may diminish the effects of antihypertensives and diuretics. Diuretics can increase the risk of nephrotoxicity of NSAIDs. It's fine to take ibuprofen with paracetamol. You can also take it alongside opioid-type painkillers such as codeine, co-codamol, tramadol or morphine. However, don't take ibuprofen with painkilling doses of aspirin, or with other related anti-inflammatory painkillers (NSAIDs) like diclofenac and naproxen, as this increases the risk of side effects on the stomach and intestines. People taking selective inhibitors of COX-2 such as celecoxib or etoricoxib should not take ibuprofen for the same reason. Nurofen Durance 200 mg Medicated Plasters contain ibuprofen. For the short-term symptomatic treatment of local pain in acute muscular strains, or sprains. Use with concomitant NSAIDs, including cyclo-oxygenase-2 specific inhibitors - increased risk of adverse reactions.

Talk to doctor if your symptoms do not improve. Your doctor will assess your condition and decide if you should continue to take the medicine. Nurofen Plus poses risks of abuse, misuse and addiction which can lead to overdose and death. Your doctor will monitor you regularly during treatment. Opioid therapy for CNCP should be initiated as a trial in accordance with clinical guidelines and after a comprehensive biopsychosocial assessment has established a cause for the pain and the appropriateness of opioid therapy for the patient (see Hazardous and harmful use, above). The expected outcome of therapy (pain reduction rather than complete abolition of pain, improved function and quality of life) should be discussed with the patient before commencing opioid treatment, with agreement to discontinue treatment if these objectives are not met.