Williams EA, Stimpson J, Wang D, Plummer S, Garaiova I, Barker ME, et al. Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study. Aliment Pharmacol Ther 2009;29:97-103. [ PubMed abstract] The ProVen Probiotics product range is supported by ongoing research and is being updated continuously.

Probiotics - Health Professional Fact Sheet Probiotics - Health Professional Fact Sheet

A Cochrane Review of 63 RCTs in a total of 8,014 participants (primarily infants and children) found that single- and multi-strain probiotics significantly shortened the duration of acute infectious diarrhea by about 25 hours. These supplements also decreased the risk that the diarrhea would last 4 or more days by 59% and led to approximately one less bowel movement on the second day in patients who received probiotics compared with patients who did not [ 19].

Caffarelli C, Cardinale F, Povesi-Dascola C, Dodi I, Mastrorilli V, Ricci G. Use of probiotics in pediatric infectious diseases. Expert Rev Anti Infect Ther 2015;13:1517-35. [ PubMed abstract] Because effects of probiotics can be specific to certain probiotic species and strains, recommendations for their use in the clinic or in research studies need to be species and strain specific [ 3, 5, 6]. Furthermore, pooling data from studies of different types of probiotics can result in misleading conclusions about their efficacy and safety. Sources of Probiotics Food Taken together, these results indicate that the effects of probiotics on body weight and obesity might depend on several factors, including the probiotic strain, dose, and duration as well as certain characteristics of the user, including age, sex, and baseline body weight. Additional research is needed to understand the potential effects of probiotics on body fat, body weight, and obesity in humans. Safety Considerations Side effects of probiotics are usually minor and consist of self-limited gastrointestinal symptoms, such as gas. In a few cases, mainly involving individuals who were severely ill or immunocompromised, the use of probiotics has been linked to bacteremia, fungemia (fungi in the blood), or infections that result in severe illness [ 69, 70]. However, some case reports did not confirm that the specific strain of probiotics used was the cause of the infection. In other cases, the probiotic strain used was confirmed to be the opportunistic pathogen. Because species used as probiotics can be normal residents of a patient’s microbiota, such confirmation is important. Sairenji T, Collins KL Evans DV. An update on inflammatory bowel disease. Prim Care 2017; 44: 673-92. [ PubMed abstract]

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As a food supplement, for best results take two capsules per day with food for a period of 1-4 months, depending on personal need. Thereafter it is usually possible to reduce to one capsule a day with food, to provide a high maintenance dose. Directions for use Production by lactobacilli and bifidobacteria of short-chain fatty acids, which lower hepatic cholesterol synthesis and regulate cholesterol metabolism [ 50-53] The potential health benefits of probiotics are the focus of a great deal of scientific research. This section focuses on research on the use of probiotics to prevent or treat seven health conditions: atopic dermatitis, pediatric acute infectious diarrhea, antibiotic-associated diarrhea (AAD), inflammatory bowel disease, irritable bowel syndrome, hypercholesterolemia, and obesity. Atopic dermatitis Allen SJ, Martinez EG, Gregorio GV, Dans LF. Probiotics for treating acute infectious diarrhoea. Cochrane Database Syst Rev 2010:CD003048. [ PubMed abstract] Makrgeorgou A, Leonardi-Bee J, Bath-Hextall FJ, Murrell DF, Tang ML, Roberts A, et al. Probiotics for treating eczema. Cochrane Database Syst Rev 2018;11:CD006135. [ PubMed abstract]Guarino A, Ashkenazi S, Gendrel D, Lo Vecchio A, Shamir R, Szajewska H, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: update 2014. J Pediatr Gastroenterol Nutr 2014;59:132-52. [ PubMed abstract] Jafarnejad S, Shab-Bidar S, Speakman JR, Parastui K, Daneshi-Maskooni M, Djafarian K. Probiotics reduce the risk of antibiotic-associated diarrhea in adults (18-64 years) but not the elderly (>65 years): a meta-analysis. Nutr Clin Pract 2016;31:502-13. [ PubMed abstract] Overall, the available evidence suggests that starting probiotic treatment with LGG or Saccharomyces boulardii within 2 days of the first antibiotic dose helps reduce the risk of AAD in children and adults age 18 to 64, but not in elderly adults. There is no evidence to suggest that the benefits are greater when more than one probiotic strain is used. Inflammatory bowel disease Researchers have studied the use of probiotics to improve lipid profiles. The mechanisms of their effects on cholesterol concentrations include catabolism of cholesterol by increasing: ProVen Probiotics Adult Acidophilus & Bifidus – 25 Billion is a high-strength friendly bacteria supplement for everyday use for adults aged 16+. Supported by a unique body of UK-based clinical research, the Lab4 live bacteria in ProVen Adult 25 Billion is the most comprehensively studied group of friendly bacteria in the UK.

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Another meta-analysis included eight randomized clinical trials with a total of 741 participants from birth to 36 months of age who were treated with Lactobacillus or Bifidobacterium for 4 to 24 weeks. The results also suggested that probiotics containing Lactobacillus might reduce atopic dermatitis symptoms in infants and toddlers, but those containing Bifidobacterium did not [ 16]. The treatment significantly improved symptoms in participants with moderate-to-severe forms of the disease but not in those with mild forms. A Cochrane Review of 39 RCTs of single probiotics and probiotic mixtures for the treatment of eczema in 2,599 participants age 1 to 55 years (most were children) found that probiotic treatment might slightly reduce SCORAD scores. However, the researchers concluded that the differences were not clinically significant and that the current evidence does not support the use of probiotics for eczema treatment [ 17]. Acute diarrhea is usually defined as loose or liquid stools and/or an increase in the frequency of bowel movements (typically at least three in 24 hours) [ 18]. Acute diarrhea can be accompanied by fever or vomiting, and it usually lasts no more than 7 days. A 2017 systematic review of 14 clinical trials, including the two described above, in 1,067 individuals with overweight or obesity showed that probiotics (mostly Lactobacillus administered at various doses for 3 weeks to 6 months) significantly decreased body weight and/or body fat in nine trials, had no effect in three trials, and increased body weight in two trials [ 61]. Another recent systematic review and meta-analysis of 15 RCTs in 957 individuals with overweight or obesity found that supplementation with various doses and strains of probiotics for 3 to 12 weeks resulted in larger reductions in body weight (by 0.6 kg), body mass index (by 0.27 kg/m 2), and fat percentage (by 0.6%) than placebo [ 62]. However, these effects were small and of questionable clinical significance. A more recent systematic review included 35 RCTs of 16 single-strain and 19 multi-strain products in 3,406 adults with IBS [ 47]. Of the studies that found a statistically significant reduction in global symptoms (14 of 29 trials) or a clinically meaningful reduction in abdominal pain (8 of 34 trials), most used multi-strain probiotic products. Furthermore, only trials of multi-strain products found a clinically meaningful improvement in quality of life [ 44, 45].With clinically-researched live bacteria, combined with specifically-selected nutrients, ProVen products are designed for all life stages and individual needs. ProVen Probiotics products are supported by more than 30 clinical trials and over ninety other studies and papers. Blaabjerg S, Artzi DM, Aabenhus R. Probiotics for the prevention of antibiotic-associated diarrhea in outpatients-a systematic review and meta-analysis. Antibiotics (Basel) 2017;6. [ PubMed abstract] Hogan DE, Ivanina EA, Robbins DH. Probiotics: a review for clinical use. Gastroenterology & Endoscopy News 2018:1-7.