Myo-Inositol & D-Chiro Inositol | Hormone Balance for Women | Ideal 40:1 Ratio | Myo Inositol 2000mg, D Chiro 50mg | Vitamin B8 to Regulate Menstrual Cycle & Support Ovarian Health | SM Nutrition

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Myo-Inositol & D-Chiro Inositol | Hormone Balance for Women | Ideal 40:1 Ratio | Myo Inositol 2000mg, D Chiro 50mg | Vitamin B8 to Regulate Menstrual Cycle & Support Ovarian Health | SM Nutrition

Myo-Inositol & D-Chiro Inositol | Hormone Balance for Women | Ideal 40:1 Ratio | Myo Inositol 2000mg, D Chiro 50mg | Vitamin B8 to Regulate Menstrual Cycle & Support Ovarian Health | SM Nutrition

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myo-Inositol (free of phosphate) was once considered a member of the vitamin B complex, called Vitamin B 8 in this context. However, because it is produced by the human body from glucose, it is not an essential nutrient. [8] Isomers and structure [ edit ] Kukuljan, M.; Vergara, L.; Stojilković, S. S. (February 1997). "Modulation of the kinetics of inositol 1,4,5-trisphosphate-induced [Ca 2+]i oscillations by calcium entry in pituitary gonadotrophs". Biophysical Journal. 72 (2 Pt 1): 698–707. Bibcode: 1997BpJ....72..698K. doi: 10.1016/S0006-3495(97)78706-X. PMC 1185595. PMID 9017197. Phytic acid". www.phytochemicals.info. Archived from the original on 2017-08-06 . Retrieved 2017-10-02. If you’re not buying Ovasitol, then it’s best to buy only pure myo-inositol. Jarrow Formulas is a well-priced and reliable brand. Pure Encapsulations also make a top-quality myo-inositol product. Phytic acid is the main source of dietary inositol. Some of the best high-inositol foods for women with PCOS include [ 7]:

A.D., et al., Modulatory role of D-chiro-inositol (DCI) on LH and insulin secretion in obese PCOS patients. Gynecol Endocrinol, 2014. 30(6): p. 438-43. Inositol is considered a safe and effective treatment for polycystic ovary syndrome (PCOS). [35] It works by increasing insulin sensitivity, which helps to improve ovarian function and reduce hyperandrogenism. [36] It is also shown to reduce the risk of metabolic disease in women with PCOS. [37] In addition, thanks to its role as FSH second messenger, myo-inositol is effective in restoring FSH/LH ratio and menstrual cycle regularization. [38] myo-Inositol's role as FSH second messenger leads to a correct ovarian follicle maturation and consequently to a higher oocyte quality. Improving the oocyte quality in both women with or without PCOS, myo-inositol can be considered as a possible approach for increasing the chance of success in assisted reproductive technologies. [39] [40] In contrast, D- chiro-inositol can impair oocyte quality in a dose-dependent manner. [41] The high level of DCI seems to be related to elevated insulin levels retrieved in about 70% of PCOS women. [42] In this regard, insulin stimulates the irreversible conversion of myo-inositol to D- chiro-inositol causing a drastic reduction of myo-inositol. myo-Inositol depletion is particularly damaging to ovarian follicles because it is involved in FSH signaling, which is impaired due to myo-inositol depletion. [11] Recent evidence reports a faster improvement of the metabolic and hormonal parameters when these two isomers are administered in their physiological ratio. The plasmatic ratio of myo-inositol and D- chiro-inositol in healthy subjects is 40:1 of myo- and D- chiro-inositol respectively. [43] The use of the 40:1 ratio shows the same efficacy of myo-inositol alone but in a shorter time. In addition, the physiological ratio does not impair oocyte quality. [44]

Minozzi, M., Nordio, M. and Pajalich, R., 2013. The combined therapy myo-inositol plus D-chiro-inositol, in a physiological ratio, reduces the cardiovascular risk by improving the lipid profile in PCOS patients. Age (years), 26(5.1). Steger, D. J.; Haswell, E. S.; Miller, A. L.; Wente, S. R.; O'Shea, E. K. (January 2003). "Regulation of chromatin remodeling by inositol polyphosphates". Science. 299 (5603): 114–116. Bibcode: 2003Sci...299..114S. doi: 10.1126/science.1078062. PMC 1458531. PMID 12434012. Chatterjee, J.; Majumder, A. L. (September 2010). "Salt-induced abnormalities on root tip mitotic cells of Allium cepa: prevention by inositol pretreatment". Protoplasma. 245 (1–4): 165–172. doi: 10.1007/s00709-010-0170-4. PMID 20559853. S2CID 9128286. Monastra, G.; etal. (2018). " alpha-Lactalbumin effect on myo-inositol intestinal absorption: in vivo and in vitro". Current Drug Delivery. 15 (9): 1305–1311. doi: 10.2174/1567201815666180509102641. PMID 29745333. S2CID 13691602. R.F., et al., The feasibility of a diet which enhances inositol availability. Progress in Nutrition, 2021. 23(2): p. e2021078.

When is the best time to take inositol for PCOS? Inositol is best taken when making changes to your diet and lifestyle. This helps further improve insulin regulation and hormone balance. The best time of day to take inositol is following the first and last meal of the day. It’s recommended to take inositol in two doses, at least six hours apart. Troisi J, Cinque C, Giugliano L, Symes S, Richards S, Adair D, et al. Metabolomic change due to combined treatment with myo-inositol, D-chiro-inositol and glucomannan in polycystic ovarian syndrome patients: a pilot study. J Ovarian Res. 2019 Mar 23;12(1):25. doi:10.1186/s13048-019-0500-x. Can I take myo-inositol during my period? Yes. Myo-inositol should be taken daily for the duration of treatment. It is suitable to use during your period. When selecting products, the first decision is what type of inositol you want to take. You have three choices:Sene AA, Tabatabaie A, Nikniaz H, Alizadeh A, Sheibani K, Alisaraie MM, et al. The myo-inositol effect on the oocyte quality and fertilization rate among women with polycystic ovary syndrome undergoing assisted reproductive technology cycles : a randomized clinical trial. Arch Gynecol Obstet. 2019;299:1701–7. R.Z., et al., Risk factors of vitamin B(12) deficiency in patients receiving metformin. Arch Intern Med, 2006. 166(18): p. 1975-9. It’s recommended that women with PCOS take a combined amount of MYO (2 to 4 grams) and DCI (50 to 100 mg) daily in the ideal physiologic ratio of 40:1. Ovasitol is what I recommend because it has passed the rigorous 3rd party testing to have the NSF certification. It’s also a tasteless and convenient powder (no more pills to swallow!) Majumder, A. L.; Biswas, B. B. (2006-10-03). Biology of Inositols and Phosphoinositides. Springer Science & Business Media. ISBN 9780387276007. Studies show that inositol supplements can reduce these risks [ 26, 27]. It’s often prescribed by physicians for the management of gestational diabetes. 5. Inositol Can Reduce Acne and Hirsutism

But the best inositol supplement for PCOS contains both myo-inositol and D-chiro-inositol. Studies show that a mixture of 40 parts myo-inositol to 1-part D-chiro-inositol is more effective than other formulations [ 49]. 40:1 is the physiological ratio that these two inositol isomers are found in the body.

Myo and D-chiro 40:1: the benefits on hyperandrogenism

PM: substantial contributions to the conception, design of the work, the acquisition, analysis and interpretation of data; have drafted the work or substantively revised it (Head of the Fertility and ART department). PJ: The acquisition of data. SB: the acquisition, analysis and interpretation of data. MLG: the acquisition of data. CR: the acquisition of data. CN: the acquisition of data. VK: design of the work, the acquisition, analysis and interpretation of data; have drafted the work or substantively revised it (Head of the Endocrinology and Metabolism department). Each author have approved the submitted version and have agreed both to be personally accountable for the author's own contributions and to ensure that questions related to the accuracy or integrity of any part of the work, even ones in which the author was not personally involved, are appropriately investigated, resolved, and the resolution documented in the literature. All authors read and approved the final manuscript. Corresponding author DiSalvo, David. "We Know About Caffeine in Energy Drinks Like Monster, But What About the Other Ingredients?". Forbes . Retrieved 2020-12-22.

V., et al., Altered Ovarian Inositol Ratios May Account for Pathological Steroidogenesis in PCOS. Int J Mol Sci, 2020. 21(19). Take my PCOS inositol quiz to find out if a 40:1 ratio is best for you. 10. Ovasitol is the Best 40:1 Ratio Brand for PCOS Despite its impact on insulin, inositol is not a good weight loss supplement. Nordio and Proietti 2012 conducted a famous trial giving women with PCOS inositol supplements. This helped with fertility but made no difference to hip-to-waist ratio or BMI [ 31]. Other trials have found the weight loss benefits to be small at best [ 17, 32]. We’re talking about only 1-2 pounds on average over 6 months of supplementation.Melo AS, Ferriani RA, Navarro PA. Treatment of infertility in women with polycystic ovary syndrome: approach to clinical practice. Clinics. 2015;70(11):765-769. doi:10.6061/clinics/2015(11)09 Lesoine B, Regidor PA. Prospective randomized study on the influence of myo-inositol in PCOS women undergoing IVF in the improvement of oocyte quality, fertilization rate, and embryo quality. Int J Endocrinol. 2016;2016:4378507.



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