PectaSol Modified Citrus Pectin Powder Super-Nutrient to Support Cellular & Immune Health, Joint Support - 454 Grams - Formulated by Dr. Isaac Eliaz of ecoNugenics

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PectaSol Modified Citrus Pectin Powder Super-Nutrient to Support Cellular & Immune Health, Joint Support - 454 Grams - Formulated by Dr. Isaac Eliaz of ecoNugenics

PectaSol Modified Citrus Pectin Powder Super-Nutrient to Support Cellular & Immune Health, Joint Support - 454 Grams - Formulated by Dr. Isaac Eliaz of ecoNugenics

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J. Ibarrola, et al., “Galectin-3 Down-Regulates Antioxidant Peroxiredoxin-4 in Human Cardiac Fibroblasts: A New Pathway to Induce Cardiac Damage,” Clin. Sci. (Lond). 132(13), 1471–1485 (2018). The most well-established pathogenic role of Gal-3 is in the development and migration of cancer. Gal-3 is over-expressed on the surface of cancer cells, acting as the primary adhesion molecule that allows cancers to proliferate, metastasize and evade the immune system. A number of scientific studies show that MCP can work synergistically with certain chemotherapy agents such as doxorubicin and paclitaxel .

PectaSol with BreastDefend was also shown to provide up to 40% greater benefits for breast cellular health, compared to using either product alone.* What’s more, MCP also lowered the rate of acute kidney injury, which went from 89% in the control group to 44% in both groups taking the modified pectin [ 14]. Improving Cognition Another randomized control trial concluded that at least 6 grams a day of pectin benefited cholesterol levels [ 6]. This trial also showed that citrus pectin was more effective than pectin derived from apples. R. Di, et al., “Pectic Oligosaccharide Structure-Function Relationships: Prebiotics, Inhibitors of Escherichia coli O157:H7 Adhesion and Reduction of Shiga Toxin Cytotoxicity in HT29 Cells,” Food Chem. 227, 245–254 (2017).A 2015 study by Tel Aviv Medical Centre Scientists showed that oral MCP supplementation could enhance the anti-metastatic and anti-cancer effects of radiotherapy in the treatment of Androgen-Independent prostate cancer(9). MCP is an important component of Complementary and Integrative Medicine (CIM).It hasbeen shown to enhance chemotherapy (even against resistant cancers) whileprotecting healthy cells fromdamagebyradiotherapy.

Research in cancer: With powerful antiadhesive, apoptosis-promoting properties, this researched MCP is shown in more than 15 published studies, including three clinical studies, to target numerous rate-limiting steps in cancer, primarily via its ability to inhibit Gal-3. 10–12 To achieve higher selectivity towards GAL3, interactions between galectins and alternative monosaccharides, including d-mannose, d-talose and d-gulose derivatives have been evaluated, although these compounds exhibited no significant functional activity in in vitro or in vivo assays 177, 178, 179, 180, 181, 182. However, a recent study reported that GAL9C and GAL9N CRDs demonstrated good affinity towards synthetic 3-deoxy-3- N-arylated-α- d-galactoside ( 4) and α-guloside ( 5) derivatives, respectively, compared with other galectins, as determined by fluorescence anisotropy assays 183 (Fig. 3c). A real paradigm shift - this book will help you really understand exactly what to do to be in great health.Z.Y. Zhao, et al., “The Role of Modified Citrus Pectin as an Effective Chelator of Lead in Children Hospitalized with Toxic Lead Levels,” Altern. Ther. Health Med. 14(4), 34–38 (2008). Galectin-3fuels chronic inflammation andits progressionin the body. It alsoaids tumour growth, metastasis and angiogenesis (new blood vessels thatsupply the tumour). Plant-derived polysaccharides have also been proposed as therapeutics for liver, kidney and lung fibrosis, mainly via mechanisms that involve inhibition of GAL3 (refs. 142, 146). Inhibition of GAL3 with belapectin ( 18, Fig. 4) and Davanat ( 19, Fig. 4) was first evaluated in a toxin-induced model of liver fibrosis 232. Intraperitoneal administration of these polysaccharides resulted in decreased collagen content, attenuated liver fibrosis, diminished cirrhosis and a reduced percentage of GAL3-expressing macrophages 232. These two inhibitors were also tested in a murine model of NASH 233. Intravenous administration of belapectin resulted in a substantial reduction in collagen deposition, hepatocellular damage, NASH activity and fibrosis

Unmodified citrus pectin does not have the same short, systemically available polysaccharide chains as MCP … and thus remains in the gastrointestinal (GI) tract. And other “modified” pectins may simply indicate that the pectin has been altered in some way, but doesn’t contain the shorter polysaccharide chains and molecular structure required for efficacy. Brouns F, Theuwissen E, Adam A, Bell M, Berger A, Mensink RP. Cholesterol-lowering properties of different pectin types in mildly hyper-cholesterolemic men and women. Eur J Clin Nutr. 2012 May;66(5):591–9. DOI: 10.1038/ejcn.2011.208. PMID: 22190137. PectaSol® Metal Detox has been clinically studied to support safe heavy metal toxin and radioactive particle removal from the body, and is formulated to provide additional support to prevent toxin reabsorption and redistribution through the gut wall.*GAL1 is upregulated in most tumour tissues and their associated stroma and has been proposed as a biomarker of poor prognosis in breast, colon, lung, prostate adenocarcinoma and melanoma 65. Tumours of the digestive tract and urinary system, as well as thyroid cancer and melanomas, express high levels of GAL3; by contrast, GAL3 expression is downregulated in tumours of the reproductive tract. Subcellular compartmentalization of GAL3 is a crucial factor contributing to its pro- or antitumoural roles. For example, increased GAL3 within the nuclear compartment has been associated with a better outcome among patients with neuroblastoma 66. On the other hand, GAL9 expression can be up- or downregulated in association with neoplastic transformation depending on the specific tumour type 65, 67. As the expression of these lectins can change during tumour progression, they have been proposed as biomarkers for diagnosis, prognosis and/or intervention in various cancer stages 65. D. Keizman, et al., Effect of Pectasol-C Modified Citrus Pectin (P-MCP) Treatment (tx) on PSA Dynamics in Non-Metastatic Biochemically Relapsed Prostate Cancer (BRPC) Patients (pts): Results of a Prospective Phase II Study,” J. Clin. Oncol. 36(6), 14 (2018).

While research is preliminary, modified citrus pectin has the potential to offer benefits for heart disease, cancer, IBS, and even cognition. It may also act as a natural chelating agent, helping individuals to safely detoxify from heavy metals.The original and only proven effective form of MCP is prepared with a proprietary, non-GMO enzymatic process controlled by pH and heat, which breaks the long chain molecules of the native pectin to produce the correct molecular size and structure of <13 kilodaltons and <5% esterification. As our understanding of the role of galectins in cancer and fibrosis has improved, various chemical and biological agents that target GAL1, GAL3 and GAL9 have been developed. These agents include small-molecule chemical inhibitors, natural polysaccharides and their synthetic derivatives, peptides and peptidomimetics, and biological agents such as small interfering RNA (siRNA), aptamers, truncated galectins and neutralizing mAbs. In the next section, we describe both the advances and the difficulties in the development and clinical evaluation of current galectin-targeted agents. Small-molecule carbohydrate inhibitors Safe heavy metal chelation: Three clinical studies highlight MCP as a safe chelator of heavy metals. MCP is shown to bind to toxic metals in the circulation, reducing blood levels and increasing the urinary excretion of lead, mercury, arsenic, cadmium and others — without disrupting essential minerals. 19–21 Another study suggested that MCP made it difficult for metastatic cancer cells to join together and grow in other parts of the body. In a small human study with prostate cancer, those taking MCP showed slower growth of PSA levels (2) .



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