Effects of berberine on diseases by regulating intestinal flora. 1. Berberine can activate TLR4/MyD88/NF-κB signal pathway to play an anti-inflammatory role, and increase the populations of Bacteroidetes, Clostridia, Lactobacillales, Prevotellaceae, Alloprevotella, Butyricimonas, Coprococcus, Ruminococcus, Lactobacillus, Akkermansia, Verrucomicrobia, reduce the populations of Bacteroidales, Lachnospiraceae, Rikenellaceae, Desulfovibrio, Streptococcaceae, Clostridiaceae, Prevotella, Proteus, Saccharibacteria, Deferribacteres, Actinobacteria, which affect the development of diabetes. 2. Berberine affects liver diseases by regulating FXR and NF-κB signaling pathways through intestinal flora. 3. Berberine down-regulate F:B ( Firmicutes : Bacteroidetes) and up-regulate SCFA-producing bacteria Allobaculum, Bacteroides, Blautia, Butyricicoccus, Phascolarctobacterium, A. muciniphila and GLP-1R in obesity. 4. Berberine regulates hyperlipidemia by reducing Prevotella, Escherichia, Clostridium Sutterella and increase Bacteroides, Parabacteroides, Blautia, Enterobacter, Akkermansia, Escherichia-Shigella, Incertae sedis, Lachnospiraceae FCS020, Clostridium sensu stricto 1. 5. In Enteropatia, berberine enriched the relative abundance of Firmicutes and decreased Proteobacteria at the phylum level. Meanwhile, berberine increased the propotion of unclassified_f_Porphyromonadaceae, unclassified_f_Lachnospiraceae, Lactobacillus, unclassified_o_Clostridiales, Ruminococcus, Prevotella, Clostridium IV, and decreased Escherichia/Shigella at the genera level. 6. Berberine affect the development of Atherosclerosis by changing the amount of Verrucomicrobia, Akkermansia in Apoe ( −/−) mice fed a high-fat diet in the intestine. Wang Y., Zhao Z., Yan Y., Qiang X., Zhou C., Li R., et al.. (2016). Demethyleneberberine Protects against Hepatic Fibrosis in Mice by Modulating NF-kappaB Signaling. Int. J. Mol. Sci. 17 ( 7), 1036. 10.3390/ijms17071036 Sekirov I., Russell S. L., Antunes L. C., Finlay B. B. (2010). Gut microbiota in health and disease. Physiol. Rev. 90 ( 3), 859–904. 10.1152/physrev.00045.2009 That’s certainly the case here, as this is one of the best berberine supplements out there that comes in a vegetarian capsule. At 500 mg per capsule, it doesn’t skimp on the dosage either. 3. Integrative Therapeutics Berberine Complex

Berberine Extract 1000mg 60 Capsules Vegan Organic Capsules Berberine Extract 1000mg 60 Capsules Vegan Organic Capsules

Lynch C. J., Adams S. H. (2014). Branched-chain amino acids in metabolic signalling and insulin resistance. Nat. Rev. Endocrinol. 10 ( 12), 723–736. 10.1038/nrendo.2014Cui H. X., Hu Y. N., Li J. W., Yuan K. (2018. a). Hypoglycemic Mechanism of the Berberine Organic Acid Salt under the Synergistic Effect of Intestinal Flora and Oxidative Stress. Oxid. Med. Cell Longev. 2018, 8930374. 10.1155/2018/8930374 Berberine’s mechanism of action is complex, but it appears to alter the way your body’s mitochondria generate energy, which might indicate why it’s helpful for such a wide variety of ailments. A. muciniphila is a gram-negative anaerobic bacterium that is selectively reduced in the fecal microbiota of patients with colitis or colitis-associated cancer (CAC). amuc_1100 is a special protein that can be isolated from the outer membrane of A. muciniphila. Once isolated, amuc_1100 still exerts biological activity and plays a beneficial role at the temperature used for pasteurization. A. muciniphila or amuc_1100 has been shown to alleviate colitis and CAC, reduce CD8 + cytotoxic T lymphocytes (cTls), and the infiltration of macrophages in the colon, and may therefore represent a promising therapeutic target for the treatment of colitis and CRC ( Wang etal., 2020). However, research has shown that the population of Akkermansia was significantly increased in a mouse model (BALB/c) of CAC fed a high-fat diet ( Wu etal., 2016). The Apc min/+ mouse model (C57BL/6J) has a tumorigenic phenotype and can develop intestinal tumors; research has shown that high-fat diet could accelerate the process of carcinogenesis. Berberine has been shown to significantly reduce intestinal-tumor development and cause changes in the structure of the GM in Apc min/+ mice (C57BL/6J) fed on a high-fat diet ( Wang etal., 2018). Berberine can clearly inhibit the increased abundance of Verrucomicrobia at the phylum level. At the genus level, berberine can suppress Akkermansia and increase the abundance of some SCFA-producing bacteria ( Wang etal., 2018). Kamada N., Seo S. U., Chen G. Y., Nunez G. (2013). Role of the gut microbiota in immunity and inflammatory disease. Nat. Rev. Immunol. 13 ( 5), 321–335. 10.1038/nri3430 These were the kinds of things we considered when evaluating the remaining berberine supplements. While a cellulose-based capsule as opposed to a gelatin-based capsule was a nice perk (for strict vegetarians and vegans), it wasn’t a core evaluation criteria.

Berberine is a promising supplement - Mayo Clinic Press

Galisteo M., Duarte J., Zarzuelo A. (2008). Effects of dietary fibers on disturbances clustered in the metabolic syndrome. J. Nutr. Biochem. 19 ( 2), 71–84. 10.1016/j.jnutbio.2007.02.009 Berberine has also been shown to significantly reduce inflammation, fibrosis, and the levels of lipid peroxides in the liver ( Zhang etal., 2016). The lipid-lowering effect of berberine occurs via a series of continuous events, including bile salt hydrolase (BSH) inhibition, significant increases in the levels of tauro-conjugated bile acids (especially TCA), and the activation of the FXR signaling pathway. These events reduce the expression levels of CD36 in the liver which then leads to a reduction in the hepatic uptake of long-chain fatty acids and the modulation of lipid metabolism in the liver ( Sun etal., 2017). Berberine’s specialized uses informed our ranking procedure: since there are several clinical trials on using berberine, we were able to compare the delivery mechanism, dosage, and purity of the products we considered to the gold standard of what’s used in scientific research. Specifically, we looked for: It accomplishes this by delivering its berberine content in MCT oil, an excellent deliver platform for the lipid-soluble biologically active compounds in berberine.Cok A., Plaisier C., Salie M. J., Oram D. S., Chenge J., Louters L. L. (2011). Berberine acutely activates the glucose transport activity of GLUT1. Biochimie 93 ( 7), 1187–1192. 10.1016/j.biochi.2011.04.013 College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China [email protected] (H.-X.C.). [email protected].

Berberine 500mg - Charava - Leading UK Brand of Berberine

Shen J., Tong X., Sud N., Khound R., Song Y., Maldonado-Gomez M. X., et al.. (2016). Low-Density Lipoprotein Receptor Signaling Mediates the Triglyceride-Lowering Action of Akkermansia muciniphila in Genetic-Induced Hyperlipidemia. Arterioscler. Thromb. Vasc. Biol. 36 ( 7), 1448–1456. 10.1161/ATVBAHA.116.307597 Thorne Research is a well-known name in the rarer, less common herbal extracts because they almost always make a quality, pure product with a minimal amount of extraneous ingredients.Hu Y., Davies G.E. Berberine inhibits adipogenesis in high-fat diet-induced 477 obesity mice. Fitoterapia. 2010;81:358–366. doi: 10.1016/j.fitote.2009.10.010. DM is a metabolic disease that is associated with high levels of morbidity and mortality. Alterations and in the GM, along with chronic systemic inflammation, have been shown to lead to DM ( Sepp etal., 2014; Cui etal., 2018a). There is increasing evidence to show that changes in the GM are associated with IR and DM. In a previous study, Gao etal. proposed that the “bacteria–mucosal immunity–inflammation–diabetes” axis can be utilized in the prevention and treatment of DM ( Gao etal., 2017). Berberine may be efficacious against DM, and has been shown to exert its actions by modulating the GM ( Zhang etal., 2015). In a previous study, Cui showed that the relative abundance of Bacteroidetes in the rat model of type II diabetes mellitus (T2DM) was lower than in normal rats; this difference was largely abolished following berberine treatment.