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Heroin which is derived from opium is most often injected, however, it may also be vaporized (or smoked), sniffed (also known as snorting), used as a rectal suppository, or orally ingested by mouth. Afghan opium poppy cultivation plunges by 95 percent under Taliban: UN". Al Jazeera . Retrieved November 7, 2023. Both analgesia and drug addiction are functions of the mu opioid receptor, the class of opioid receptor first identified as responsive to morphine. Tolerance is associated with the superactivation of the receptor, which may be affected by the degree of endocytosis caused by the opioid administered, and leads to a superactivation of cyclic AMP signaling. [155] Long-term use of morphine in palliative care and the management of chronic pain always entails a risk that the patient develops tolerance or physical dependence. There are many kinds of rehabilitation treatment, including pharmacologically based treatments with naltrexone, methadone, or ibogaine. [156]

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Heroin (diacetylmorphine) is derived from the morphine alkaloid found in opium and is roughly 2 to 3 times more potent. A highly addictive drug, heroin exhibits euphoric ("rush"), anxiolytic and analgesic central nervous system properties. Heroin is classified as a Schedule I drug under the Controlled Substances Act of 1970 and as such has no acceptable medical use in the United States. Senlis Council (September 26, 2005). "The Kabul International Symposium on Drug Policy". Archived from the original on March 13, 2007 . Retrieved May 4, 2007. Opium smoking began only after the early Europeans in North America discovered the Indian practice of smoking tobacco in pipes. Some smokers began to mix opium with tobacco in their pipes, and smoking gradually became the preferred method of taking opium. Opium smoking was introduced into China from Java in the 17th century and spread rapidly. The Chinese authorities reacted by prohibiting the sale of opium, but these edicts were largely ignored. During the 18th century European traders found in China an expanding and profitable market for the drug, and the opium trade enabled them to acquire Chinese goods such as silk and tea without having to spend precious gold and silver. Opium addiction became widespread in China, and the Chinese government’s attempts to prohibit the import of opium from British-ruled India brought it into direct conflict with the British government. As a result of their defeat in the Opium Wars, the Chinese were compelled to legalize the importation of opium in 1858. Opium addiction remained a problem in Chinese society until the Communists came to power in 1949 and eradicated the practice.Extensive textual and pictorial sources also show that poppy cultivation and opium consumption were widespread in Safavid Iran [42] and Mughal India. [43] England [ edit ] Darke S, Zador D (December 1996). "Fatal heroin 'overdose': a review". Addiction. 91 (12): 1765–72. doi: 10.1046/j.1360-0443.1996.911217652.x. PMID 8997759.