This biomass was then combined to create a proxy form, through which Vecna could directly act in the human world; like the Mind Flayer, this proxy form also resembled a spider, and had the same flame-shaped head. The human version of the character was first revealed on November 20, 2020 via the show's official social media accounts, along with several other new characters. He graduated from Regis College in 2019 with a Bachelor's in Communication and minored in both Film Studies and Writing. The group raced to play Max's favorite song over her Walkman and headphones, before watching in horror as she started to levitate above Billy's grave. Unfortunately, Vecna managed to corner Max and while he appeared to show a small degree of respect as he complemented her for her bravery, he ultimately deemed her weak like Billy, her friends and the rest of mankind.

Victor was told that Henry died a week later due to shock, but in truth, his death was a hoax orchestrated by Dr. Fred initially looked like a smart and brilliant teenager with an interest in becoming a reporter but soon enough, he became Vecna's second target.

While the afflicted Fred stood where the accident had happened, Vecna struck the killing blow, killing Fred and opening a second gate beneath the cement. He proceeded to reveal his secret origins through a series of visions, discombulating Nancy as she lived through scattershot points from Henry's past.

Henry discovered he possessed, or had somehow developed, remarkable psychokinetic abilities, finding he could manipulate the grandfather clock downstairs with the power of his mind alone. When Vecna revealed his plan to invade the human world via the curse gates, Max demonstrated courage when she volunteered to bait Vecna into possessing her again. Patrick's death created Vecna's third gate in the bottom of the lake and convinced Jason more than ever that Eddie and his Hellfire Club were responsible for the murders. After Eleven sent Henry through the gate, he was jettisoned to a strange inter-dimensional space beyond the human world.He inserted Soteria into Henry's neck, a miniature device that suppressed his powers and tracked his every movement; in Henry's own words, he had become a 'prisoner'. Through the hive mind, a diverse range of beings fell under Vecna's control, including "demogorgons", the "Flayed" of 1985, and "demobats", as well as the roots and vines strewn across the surface of the Upside Down. After witnessing her being bullied by the other test subjects, he believed both of them were similarly misunderstood, and also believed Eleven to be the most powerful of the test subjects.

Henry proceeded to go on a murderous rampage throughout the laboratory, killing all the other test subjects and various Hawkins Lab personnel, and indirectly knocked Dr. Henry would prove to be highly manipulative and cunning when he convinced Eleven to remove the 'Soteria' neck chip suppressing his powers.Vecna had no time to gather his bearings and fight back, having been weakened by Eleven, Murray and the Molotovs all at once. After Henry transforms into the being known as Vecna, he becomes even more malevolent, delighting in the torment he inflicts upon others. Most notably, a deconstructed and fragmented version of Henry's childhood home laid at the realm's center. Victor's paranoia drove him to believe a demon lived inside their home, though Virginia began to suspect these happenings were somehow the doing of her son. Henry explained himself to Eleven, telling her of his origins and philosophy; he asked her to join him in his goal to eradicate humanity.