Anthelmin Plus Flavour Single Tablet for Dogs - 1 x Single Tablet

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ADRs identified from clinical trials and post-marketing experience with Anthelmin are included in Table 1. The displayed frequency categories use the following convention: Tapeworms - these worms live in the gut. People usually become infected by eating raw or uncooked meat. Following oral administration, < 10% of the dose reaches the systemic circulation, due to incomplete absorption and to extensive pre-systemic metabolism (first-pass effect). Maximum plasma concentrations are generally seen 2 to 4 hours after administration. Dosing with a high fat meal leads to a modest increase in the bioavailability of mebendazole. Most worm infections occur in warm tropical countries or developing countries where food and water may not be clean. It is thought that millions of people around the world are infected with worms at any one time.

Roundworms - the most common roundworm infections are thought to be caused by threadworms, ascaris, hookworms and trichuris. Roundworm eggs usually enter the body by the person eating food or drinking water that contains eggs. The eggs live and hatch in the gut (intestine). b ADRs not observed in clinical trials and frequency calculated using “Rule of 3”, as detailed in SmPC guideline 2009. 6276 patients exposed in clinical trials and epidemiological studies, divided by 3 (Frequency = 1/2092). Note: frequencies differ from those reported in the August 2009 CCDS, as these were not calculated using the formula detailed in the SmPC guideline 2009. Other types of worm infections can occur if you live in the UK; however, they do not occur very often. People who get these infections have usually been travelling in countries where these types of worm infections are common.Do not use the product in the first two thirds of pregnancy. The product may be used during lactation. The safety of Anthelmin was evaluated in 6276 subjects who participated in 39 clinical trials for the treatment of single or mixed parasitic infestations of the gastrointestinal tract. In these 39 clinical trials, no adverse drug reactions (ADRs) occurred in >1% of Anthelmin-treated subjects. crush it in their food. If your vet says the tablet can be crushed up and given with food, try crushing it up and mixing it with one of their daily meals (ideally breakfast depending on the time you need to give them their tablet). Make sure they eat all their meal, though, otherwise they may miss some of their medication. Or you could try mixing it, unless your cat is sensitive to the ingredients, in a soft yoghurt-textured treat for cats Anthelmin Plus Flavour and Anthelmin Plus XL - Consult a veterinary surgeon before treating pregnant animals for roundworms. hide it in something strong smelling. Cats are very sensitive to smells (which is why they can usually find their tablet in their food). Try using a little of something strong smelling, like tuna, to hide the tablet in

particular, the activity spectrum covers Toxocara canis , Toxascaris leonina , Uncinaria stenocephala and Ancylostoma Orally administered mebendazole is extensively metabolised primarily by the liver. Plasma concentrations of its major metabolites (amino and hydroxylated amino forms of mebendazole) are substantially higher than those of mebendazole. Impaired hepatic function, impaired metabolism, or impaired biliary elimination may lead to higher plasma levels of mebendazole. The tablet(s) can be given directly to the dog or disguised in food. No restriction of access to food is required either before or after administration of the product. To ensure administration of a correct dose, body weight should be determined as accurately as possible. Puppies may be wormed with this product from 2 weeks of age and every 2 weeks until 12 weeks of age. Thereafter they should be treated at 3 monthly intervals until 6 months of age.

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In the interests of good hygiene, persons administering the tablet directly to a dog or by adding it to the dog's food, should wash their hands afterwards. particular Taenia spp. and Dipylidium caninum .Praziquantel acts against adult and immature forms of For the control of Toxocara, nursing bitches should be dosed 2 weeks after giving birth and every 2 weeks until weaning. For adult dogs, a single dose should be used. The advice of a veterinarian should be sought regarding the need for and frequency of repeat treatment. In the event of a heavy roundworm infestation, a repeat dose should be given after 14 days. Table 1: Adverse Drug Reactions Reported in Clinical Trials and Post-marketing Experience for Anthelmin Special precautions to be taken by the person administering the veterinary medicinal product to animals

Anthelmin Plus Flavour – For treatment of dogs administer 1 tablet per 10kg bodyweight (15 mg/kg bodyweight febantel, 14.4 mg/kg pyrantel and 5 mg/kg praziquantel). This is equivalent to 1 tablet per 10 kg bodyweight. Tablets may be halved/quartered to allow accuracy of dosing. Anthelmin Plus XL 1 tablet per 35 kg bodyweight. Tablets may be halved to allow accuracy of dosing.The rest of this leaflet discusses the medicines that may be used to treat worm infections. See the separate leaflets called Roundworms, Threadworms and Schistosomiasis. Anthelmin Plus Flavour– For treatment of dogs administer 1 tablet per 10kg bodyweight (15 mg/kg bodyweight febantel, 14.4 mg/kg pyrantel and 5 mg/kg praziquantel). This is equivalent to 1 tablet per 10 kg bodyweight. Tablets may be halved/quartered to allow accuracy of dosing. Flukeworms - these worms can live in the blood vessels, gut, lungs or liver. You usually become infected with flukeworms by swimming or washing in fresh water that contains flukeworms. An infection with flukeworms causes a tropical disease called schistosomiasis. Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via:

Very common (>1/10); Common (>1/100 to <1/10); Uncommon (>1/1000 to <1/100); Rare (>1/10,000 to <1/1000); Very rare (<1/10,000), Not known (cannot be estimated from the available data). Mebendazole, the conjugated forms of mebendazole, and its metabolites likely undergo some degree of enterohepatic recirculation and are excreted in the urine and bile. The apparent elimination half-life after an oral dose ranges from 3 to 6 hours in most patients.