Cerebrolysin : The Next Evolution of Medicine

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The main ways of administering the drug are intramuscular (IM) and intravenous (IV). The gluteal region is the best spot to inject IM. Relax your muscle and inject slowly. Here are a couple of tips on how to make injections. Please follow the sterility instructions! What are Cerebrolysin Side Effects?

Chen H, Tung YC, Li B, Iqbal K, Grundke-Iqbal I (2007) Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis. Neurobiol Aging 28(8):1148–1162. https://doi.org/10.1016/j.neurobiolaging.2006.05.036 Cerebrolysin should be applied only parenterally: intramuscular injection (5ml) or intravenous drip infusion (10ml). The dose and duration depends on the nature and severity of the disease, as well as the patient’s age. It is possible to administer a single dose of 50 ml , but more preferably, a course of treatment – daily injection for 10-20 days. Guekht A, Vester J, Heiss W-D, Gusev E, Hoemberg V, Rahlfs VW, Bajenaru O, Popescu BO, Doppler E, Winter S, Moessler H, Muresanu D (2017) Safety and efficacy of Cerebrolysin in motor function recovery after stroke: a meta-analysis of the CARS trials. Neurol Sci 38(10):1761–1769. https://doi.org/10.1007/s10072-017-3037-z Use only sterile, single use syringes (or single use one-way infusion kits). Recommended to use sterile plastic gloves. Thome J, Doppler E (2012) Safety profile of Cerebrolysin: clinical experience from dementia and stroke trials. Drugs of today 48 Suppl A, 63-69.i] Plosker, G. L., & Gauthier, S. (2009). Cerebrolysin: a review of its use in dementia. Drugs & aging, 26(11), 893–915. https://doi.org/10.2165/11203320-000000000-00000 Heiss WD, Brainin M, Bornstein NM et al. (2012) Cerebrolysin in patients with acute ischemic stroke in Asia: results of a double-blind, placebo-controlled randomized trial. Stroke; a journal of cerebral circulation 43, 630-636.

Vascular dementia is a common form of dementia caused by poor blood flow to the brain. There are currently no proven and licenced treatments for vascular dementia. Cerebrolysin is a medicine that is made from pig's brains and given as an injection. In some countries, Cerebrolysin is used as a treatment for vascular dementia. A previous summary from 2013 considered all studies of Cerebrolysin and vascular dementia. A definitive conclusion as to whether Cerebrolysin was beneficial could not be made. Gavrilova SI, Alvarez A (2020) Cerebrolysin in the therapy of mild cognitive impairment and dementia due to Alzheimer’s disease: 30 years of clinical use. Med Res Rev. https://doi.org/10.1002/med.21722 We searched for studies that described the effect of Cerebrolysin in people living with vascular dementia. We searched databases of scientific studies, including resources from countries where Cerebrolysin is commonly used. To be included in our review, the studies had to randomly decide whether people were treated with Cerebrolysin or a comparison. We combined the results of the included studies to estimate the effect of Cerebrolysin. We also assessed how well the studies were conducted and how credible the results were. The evidence is current to May 2019.

A relatively unique discovery about the properties of Cerebrolysin is that it can help to control pain. Research in rats shows that Cerebrolysin can help to reduce pain and other symptoms associated with migraine. Measurement of pro-inflammatory cytokines like TNF-alpha and IL-1B shows that these pain-causing molecules are decreased following administration of Cerebrolysin[19]. These studies were carried out on rat models of chronic migraine, suggesting that Cerebrolysin may be particularly useful in those who suffer the most from these debilitating headaches. Given the difficulty of treating migraines, particularly chronic migraines, this finding represents an important step toward improved well-being for tens of thousands of individuals. Stepanichev M, Onufriev M, Aniol V, Freiman S, Brandstaetter H, Winter S, Lazareva N, Guekht A, Gulyaeva N (2017) Effects of cerebrolysin on nerve growth factor system in the aging rat brain. Restor Neurol Neurosci 35(6):571–581. https://doi.org/10.3233/rnn-170724 S Gavrilova, A Alvarez (2021) Cerebrolysin in the therapy of mild cognitive impairment and dementia due to Alzheimer’s disease: 30 years of clinical use https://pubmed.ncbi.nlm.nih.gov/32808294/ ALL products and services offered are for IN-VITRO RESEARCH purposes ONLY and are NOT TO BE INGESTED or CONSUMED IN ANY MANNER. Ziganshina et al (2016) Cerebrolysin for acute ischaemic stroke https://www.ncbi.nlm.nih.gov/pubmed/27918088

The Cochrane review suggests benefit of Cerebrolysin and I see no reason to disagree with this conclusion. The review was high quality, the search was comprehensive including foreign language publications and quality assessment was thorough. Only one study An investigation of a healthcare problem. There are different types of studies used to answer research questions, for example randomised controlled trials or observational studies. was rated as being at risk A way of expressing the chance of an event taking place, expressed as the number of events divided by the total number of observations or people. It can be stated as ‘the chance of falling were one in four’ (1/4 = 25%). This measure is good no matter the incidence of events i.e. common or infrequent. of bias and sensitivity A measure of a screening or diagnostic test’s ability to correctly detect people who have the disease. analysis showed that omitting this trial would not have altered the obtained results.Ladurner et al (2004) Neuroprotective treatment with Cerebrolysin in patients with acute stroke: a randomised controlled trial https://www.ncbi.nlm.nih.gov/pubmed/15583955

Alcantara-Gonzalez et al (2012) Combined Administration of Cerebrolysin and Donepezil Induces Plastic Changes in Prefrontal Cortex in Aged Mice https://www.ncbi.nlm.nih.gov/pubmed/22826038 Intravenous administration of Cerebrolysin can enhance the cognitive abilities in patients with dementia. Cerebrolysis is administered as a daily dose for a different time period depending on the duration and severity of the disease. In a clinical trial, the cognitive function of the patients was assessed after Cerebrolysin administration with the help of different techniques such as arithmetic, recalling, and other abilities. All the assessments determined significant improvement. Skvortsova V, Shamalov N, Stakhovskaya L (2005) Cerebrolysin in acute ischaemic stroke: results of randomised, double blind, placebo-controlled study. Cerebrovasc Dis 19:76 ii] Ghaffarpasand, F., Torabi, S., Rasti, A., Niakan, M. H., Aghabaklou, S., Pakzad, F., Beheshtian, M. S., & Tabrizi, R. (2018). Effects of cerebrolysin on functional outcome of patients with traumatic brain injury: a systematic review and meta-analysis. Neuropsychiatric disease and treatment, 15, 127–135. https://doi.org/10.2147/NDT.S186865

How to Inject Cerebrolysin?

Please note that it is important to follow the recommendations of the drug administration to minimize the chance of adverse reactions.