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The Primal Defense Ultra is their own in-house HSO formula which blends 12 species of microorganisms and minerals, giving you probiotic capsules specifically designed to balance gut flora. Although probiotics are generally recognized as safe, if you have a compromised or weakened immune system (like if you have chemotherapy treatments, a critical illness or you’ve recently had surgery) you should avoid taking probiotic supplements and probiotic foods.
Fang, X. et al. Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer’s disease and Parkinson’s disease. Amb. Express 10, 13 (2020).
Chong, J. & Xia, J. G. Computational approaches for integrative analysis of the metabolome and microbiome. Metabolites 7, 10 (2017). Bhattarai, Y. & Kashyap, P. C. Parkinson’s disease: are gut microbes involved? Am. J. Physiol. Gastrointest. Liver Physiol. 319, G529–G540 (2020). Gefenaite, G. et al. Longitudinal association between housing accessibility and activities of daily living: the role of self-efficacy and control in people ageing with Parkinson’s disease. BMC Geriatr. 20, 181 (2020). To find out how many colony-forming units you need to help with a specific condition, you should speak to a doctor before casually starting probiotic supplements to make sure they’re right for you. Storage and expiration information
Jameson, K. G. et al. Toward understanding microbiome-neuronal signaling. Mol. Cell 78, 577–583 (2020).Kang, D. W. D. et al. MetaBAT 2: an adaptive binning algorithm for robust and efficient genome reconstruction from metagenome assemblies. Peerj 7, 13 (2019). Valles-Colomer, M. et al. The neuroactive potential of the human gut microbiota in quality of life and depression. Nat. Microbiol. 4, 623–632 (2019). GenScript ProBio’s total CGT solution covers CMC of plasmid and virus for IND filing as well as clinical manufacturing and commercial manufacturing. GenScript ProBio’s innovative solutions for biologics discovery and development include therapeutic antibody discovery, antibody engineering and antibody characterization. In the biologics CDMO service, GenScript ProBio has built a DNA to GMP material platform, including stable cell line development, host cell commercial license, process development, analytical development to clinical and commercial manufacturing, and offer fed-batch and perfusion processes to meet the growing needs for antibody and protein drugs. GenScript ProBio has established GMP capacity that meets regulatory requirements of the US Food and Drug Administration (FDA), European Medicines Agency (EMA) and National Medical Products Administration (NMPA). The gut microbiota of patients with PD was reported to have reduced carbohydrate fermentation and butyrate synthesis capacity and increased proteolytic fermentation compared with healthy individuals 6. Some taxa in the phylum Firmicutes, such as Butyricimonas and Clostridiam clusters IV and XIV, have been considered as protagonists of carbohydrate fermentation and butyrate production 48, 49. Our study found that some SGBs in Firmicutes ( Butyricimonas sp. CAG:1, Lachnospira eligens, Clostridiales sp. CAG:26, etc.) increased after probiotic intake. Moreover, SGBs involved in SCFAs (butyrate, isovaleric acid, and propionate) synthesis increased in the Probio-M8 group after intervention. Bacteroides were reported to be GABA-producers, and their relative abundance correlated negatively with the brain signatures associated with depression 15. Interestingly, our data showed that more GABA synthesis modules-encoding SGBs were identified in the probiotic group; and more Bacteroides intestinalis was found in the Probio-M8 group, which was associated with increased MMSE scores as well. Our data also showed that more SGBs representing Prevotella and Lactobacillus were found in the placebo group after the course of intervention. Prevotella were found to increase in patients with PD, and they played important roles in the metabolism of mucus layer glycoprotein, the permeability of the intestinal barrier, and inflammation 50, 51. Some Lactobacillus could produce specific enzymes that convert levodopa into dopamine before it reaches the brain, thus decreasing the drug efficacy and increasing the required dose for clinical effectiveness 13, 52. Our results showed that the abundance of L. fermentum in the placebo group was significantly associated with a less fit mental state (characterized by higher scores of HAMA and HAMD; lower scores of MMSE) and more serious illness (characterized by higher scores of UPDRS). In addition, some neuroinflammation-associated pathogens decreased after Probio-M8 intervention, such as P. distasonis, Evtepia gabavorous, and, K. oxytoca. The species, P. distasonis, correlated negatively with hippocampal function, while K. oxytoca could induce anxiety and colitis, and the population of apoptotic neuron cells in the brain of mice via production of lipopolysaccharide and enterotoxins 53, 54, 55. In our study, K. oxytoca was found to be significantly and negatively associated with feces hardness in patients with PD. Therefore, it was likely that the clinical remissive effect of Probio-M8 was related to the regulation of specific gut microbiota in patients with PD.
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