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With that surging interest has come an unprecedented amount of fraud and adulteration, putting consumers and the entire NMN industry at risk. In addition to that real-world experience with NMN, our team has pored over dozens of scientific journal articles devoted to NAD production and NMN metabolism. All of this preparation allows us to confidently suggest which available supplements stand the best chance of increasing your NAD levels. This is a gel that you administer orally. It contains 240mg of NMN and 40 mg of resveratrol. Some experts believe that resveratrol acts synergistically with NMN, but most of the research into the issue is inconclusive. A: We don’t know yet. It’s highly likely that NMN will be pulled from the market by the FDA, but the FDA doesn’t always enforce their own policy decisions. In the case of the product NAC, the FDA issued a policy statement that designated NAC as a drug but also issued an official policy statement that they won’t enforce the policy. So NAC is still widely available in the US. The NMN situation is different from NAC though in a material way. No pharmaceutical company had a vested interest in making NAC only available as a drug, whereas there is a pharmaceutical company with a strong financial interest in making NMN only available as a drug.
As many of you probably already know, the FDA notified several NMN manufacturers late last year that they had classified NMN as a drug, which means that it can't be sold as a supplement. This type of initial FDA notice is often challenged and can take years to litigate before there's broad enforcement. Due to this we had advised our customers to wait until the ruling was final and enforced before taking action. Liao, B., Zhao, Y., Wang, D., Zhang, X., Hao, X., and Hu, M. (2021). Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. Journal of the International Society of Sports Nutrition, 18, 54. During a meeting on Friday, Dan Fabricant, the head of the Natural Products Association (the NPA) explained that although everyone hopes the citizen's petition leads to an FDA policy reversal on NMN, the filing is meaningful regardless of the FDA's response because it will ultimately allow the trade organizations the right to sue the FDA. Now that the citizen's petition has been filed the FDA has 180 days to respond. Often, they don't respond to citizen's petitions, but in both the case of a denial of the petition or a non-response the NPA and ANH gain the legal right to sue. Bai, B., Yau, F., Tong, T., Chan, H., Zhang, W., & Jiang, H. (2022). Improvement of tissue‐specific distribution and biotransformation potential of nicotinamide mononucleotide in combination with ginsenosides or resveratrol. Pharmacology Research & Perspectives, 10(4). Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that dramatically improves health and longevity by serving as a precursor to NAD+.
A Perfectly Balanced Combination of NMN, Trans-Resveratrol and TMG
Feng Z, Qin Y, Huo F, et al. NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury. Biochim Biophys Acta Mol Basis Dis. 2022;1868(1):166287. doi:10.1016/j.bbadis.2021.166287 Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M. Nicotinamide mononucleotide supplementation A: We don’t know much about the investigational drug version of NMN. Natural NMN found in food is unstable and occurs in such small quantities that it would be impossible to sell an extract made of natural, unrefined NMN. We know that all supplement and drug forms of NMN are manufactured, refined, stabilized, etc… but we don’t know the differences. The picture is muddy, and we’ll dive a little deeper into the risks and the relevant research in our safety section below, but those with cancer currently, cancer in remission, or a history of cancer in their family might want to consider alternatives to achieving wellness goals. As with many supplements and medications, the lowest dose that gives you benefit is ideal, so supplements that provide lower doses — or give you control over the dose (like a powdered NMN supplement) — may be preferable from a safety standpoint. Convenience
Imai, S. I. (2011). Dissecting Systemic Control of Metabolism and Aging in the NAD World: The Importance of SIRT1 and NAMPT-mediated NAD Biosynthesis. FEBS Letters, 585(11), 1657. There are three ways companies approach solving this bioavailability conundrum, and we’ll describe those in detail below in our section on how NMN supplements work. To help you understand how we applied these solutions to our efficacy rating, we’ll say that we prefer as direct an influx of NMN to the bloodstream as possible. Sublingual powders or liquids, dissolving tablets, and nasal sprays are the best delivery mechanisms for sending NMN straight to the bloodstream without involving the GI tract. A: We’re working with our suppliers to bring costs down, but at least initially many of the new NAD+ supplements will be more expensive than NMN. That said, they will also be more concentrated so less will be needed to accomplish the same outcome. The price of NMN dropped significantly over the last few years. We expect that with volume and manufacturing innovations costs and prices will come down on our new products too. NMN Pro Powder allows NMN to be absorbed directly into the blood vessels in the mouth and under the tongue, which increases the product's bioavailability. In this way, NMN avoids digestion in the gastrointestinal tract and can be more rapidly delivered into the bloodstream.
ProHealth NMN Powder
No safety or efficacy objection was mentioned by the FDA, and the notification was rejected purely on the basis of their designation of MIB-626 (Metro Biotech's highly refined form of NMN) as an Investigational New Drug. Unfortunately, the FDA recently reaffirmed its position on NMN in their response to our Uthever NMN New Dietary Ingredient Notification. Even though the application included everything required to qualify for a supplement designation and was filed by our manufacturing partner prior to the unprecedented change in FDA policy last year, the FDA rejected the notification. Li, D., Tian, Y. J., Guo, J., Sun, W. P., Lun, Y. Z., Guo, M., Luo, N., Cao, Y., Cao, J. M., Gong, X. J., & Zhou, S. S. (2013). Nicotinamide supplementation induces detrimental metabolic and epigenetic changes in developing rats. The British Journal of Nutrition, 110(12), 2156–2164. Only Clincially-Proven NMN. ProHealth’s NMN is the only clinically-proven NMN to boost NAD+ levels in a peer-reviewed, double-blind, placebo-controlled, published, clinical study. Results of the study indicated a 38% increase in NAD+ levels and 12-year reversal in biological age.
Suggested Use: Take 2-4 capsules daily, with or without food, preferably in the morning, or as directed by your healthcare practitioner. Ramírez-Garza, S. L., Laveriano-Santos, E. P., Marhuenda-Muñoz, M., Storniolo, C. E., Tresserra-Rimbau, A., Vallverdú-Queralt, A., & Lamuela-Raventós, R. M. (2018). Health Effects of Resveratrol: Results from Human Intervention Trials. Nutrients, 10(12). Because we are on the front line, we knew the spike in the number of retail suppliers and products wasn't logical. We wanted to protect ourselves and others from what was going on. Our first step was to shore up the integrity of our supply chain and formalise our relationship with Effepharm, manufacturers of Uthever, the only soon-to-be GRAS NMN.NMN is a natural metabolite of vitamin B3 and a precursor to NAD+ which supports myriad functions essential to health and healthy aging. NAD+ levels decline in human tissue by at least 50 percent between the ages of 40 and 60. Taking NMN boosts natural NAD+ production, and provides the body with energy for gene repair and stimulation. Be Aware of Fake NMN: Fraudulent companies are always attempting to out-price competitors by using NMN fake ingredients to gain market share, which is not fair to you, the consumer, or the reputable companies, like ProHealth that spends time and resources to ensure a safe and pure NMN product. TMG is a methyl donor that complements NMN supplementation by helping replenish the body's methyl pool. While they may be faster-acting, sublingual delivery doesn’t seem to increase long-term bioavailability, at least according to one vitamin B study. 13 And lipid nanocarriers can theoretically protect NMN until it gets to the small intestine, where a dedicated NMN transporter is waiting to help you absorb it. But there’s more than one type of liposomal delivery system, and each will act differently in delivering specific elements or compounds. 14 It is anticipated that results of this largest and most comprehensive human clinical trial on NMN to date will be published in the near future. Additionally, ProHealth Longevity is conducting its own multi-center, placebo-controlled clinical trial, an unusual step for an ingredient wholesaler/retailer. ProHealth Longevity
Yoshino, J., Mills, K. F., & Yoon, M. J. (2011). Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metabolism, 14(4), 528. At Innerbody Research, we extensively test each health service we review, including these NMN supplements. All told, our team has spent over 337 hours testing and researching these supplements and the customer service their manufacturers provide. So let's tell our representatives in Washington that we want access to safe and effective natural ingredients like NMN to be protected. Using the link below you can send a form letter to your representatives in DC in just a few seconds. These letters do matter. If we all take less than 1 minute out of our day to send one, we may change FDA enforcement policy. Adding even more to our credibility, the Uthever Scientific Quality Standard Setting Team is under the direction of a former (USP) scientist who ensures that Uthever® NMN Pro capsules are in strict accordance with USP quality standards. It’s true that there have been some significant side effects documented in resveratrol studies, including nausea, vomiting, diarrhea, and even liver problems. But these issues arose in studies that looked at doses up to 100 times higher than what you often find in NMN supplements. And a lot of resveratrol research reveals that its positive and negative actions in the body are dose-dependent. 12 That means that it can be tremendously beneficial to the body in small quantities, like the ones mixed with NMN in various supplements.
Thank you for your loyalty over the last 3 decades, and please reach out if you have any questions or concerns.
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