Joined in 2023 
82 
63 About this deal
The probes do not carry firearms and whilst they and other characters are regularly in jeopardy, deaths are rare. Albert Popwell as Albert Griffin, linguist and code-breaker; former chief translator at the United Nations M. Claesson, V. Siitonen, D. Dobritzsch, M. Metsä-Ketelä and G. Schneider, FEBS J., 2012, 279, 3251–3263 CrossRef CAS PubMed.
The most difficult and sensitive assignments fall to the W.C.C.'s supersecret branch: Programmed Retrieval Operations, referred to as "Probe." The agents of Probe rival those of the CIA or MI-5, and are equipped with unique devices that even real-life 21st-century spooks would envy. A mysterious individual known only as "Saratoga" hires Probe Division to investigate a State Department official's disappearance. In the category of computational resources, ProbeMiner serves as a source for objective, quantitative, data-driven probe assessment. These two databases can be viewed as complementary to each other. We noticed that the identified BGCs included many known BGCs for type II polyketide biosyntheses such as enterocin, 23 landomycin, 24 and tetracenomycin, 25 indicating that they also share a similar resistance mechanism (Fig. S1 †). To directly target the tetracycline BGC, we attempted to analyze the CLFs, whose phylogeny highly correlates with the polyketide condensation number and cyclization pattern. 26,27 To test if the tetracycline BGCs are in a separate clade, we first generated a phylogenetic tree using CLFs from over 160 characterized BGCs for type II PKS. Indeed, we found that the compounds with different extension lengths and cyclization patterns can be well distinguished (Fig. S2 †). Gratifyingly, we observed that five known CLFs from tetracycline BGCs are grouped together, although they are closely related to the BGC from cervimycin, supporting the feasibility of the CLF phylogeny in reflecting the product structure. Thus, the CLF sequences from 1744 BGCs were extracted and a phylogenetic tree was then constructed ( Scheme 1D). The most abundant BGCs are angucyclines. Meanwhile spore pigment, naphthoquinone, pentangular polyphenol, and anthracycline BGCs were also widely distributed, indicating that the TetR/MarR-transporter resistance mechanism is widespread in the type II PKS biosynthetic pathway. Notably, we observed a small group that contained 103 CLFs including 5 known tetracycline CLFs clustered together. Among them, 72.8% are from Streptomyces, 14.5% are from Kitasatospora, 4.8% are from Amycolatopsis, and the others are from rare actinomycetes like Spongiactinospora and Micromonospora, indicating a wide spread of tetracycline BGCs in various strains (Fig. S3 †). After dereplication, we obtained 25 BGCs that are distinct from all characterized tetracycline BGCs in the literature (Fig. S4 and Tables S3–S27 †).
Abstract
Had this and "One of our Probes . . ." been aired in production number sequence, this would have introduced Burrell; dialogue when Burrell takes over Harding's station suggests this was the intent. J. Zwahlen, S. Kolappan, R. Zhou, C. Kisker and P. J. Tonge, Biochemistry, 2007, 46, 954–964 CrossRef CAS PubMed.
This usage of chemical probes, while consistent with recent drug discovery terminology, should not be confused with probes used in genomics research—DNA or RNA sequences labeled with fluorescent or radioactive tags that can be used to search for their complementary sequences in a sample genome. Searching for a stolen statue of Kali, Grover finds himself battling an apparent resurgence of the Cult of Thugs. Includes two scenes with Cameron outside Probe Control, and the only on-screen appearance of the Probe Control briefing narrator, played by Vernon Weddle, whose voice is heard in other episodes and the pilot movie.Postcodes for Highlands and Islands of Scotland, N Ireland, Isle of Man & Isles of Scilly, Channel Islands and Isle of Wight are: FK17-99, G83, KW1-14, IV, HS, KA27-28, PA20-49, PA60-78, PH15-26, PH30-44, PH49-50, ZE, AB51 Each field agent is outfitted with a miniature scanner disguised as a piece of jewelry, which can be magnetically attached to special cufflinks, tieclips, or pendants. This device continuously monitors the agent's progress, transmitting audio, video, and phyiscal telemetry to Probe Control. A team of specialists at Probe Control analyze the data, consult databases worldwide, and immediately provide information covertly to the field agent via a subcutaneous earpiece. The agent can respond to Probe Control either audibly or by tapping out code with a dental implant. Chemical probes are small-molecule compounds known to modulate a particular protein target in a particular way. They can then be used in drug discovery and development to investigate the effects of modulating that target or pathway. Using a probe can preview whether a drug aimed at the same target could be effective before you embark on the long and costly process of development and clinical trials.
J. D. Rudolf, X. Yan and B. Shen, J. Ind. Microbiol. Biotechnol., 2016, 43, 261–276 CrossRef CAS PubMed.J. Shi, C. L. Liu, B. Zhang, W. J. Guo, J. P. Zhu, C. Y. Chang, E. J. Zhao, R. H. Jiao, R. X. Tan and H. M. Ge, Chem. Sci., 2019, 10, 4839–4846 RSC. The brilliant but mentally unstable inventor of a device capable of remotely overloading and destroying any active electrical or electronic circuit is attempting to destroy Probe Control. Angel Tompkins as Gloria Harding, senior medical technician monitoring pulse, respiration, and temperature
Great Deal 
New Comment