Lugols 12% Iodine Solution, High Strength, True 12% Liquid Formulation, Bulb Pipette for Easy & Accurate Dispensing, Formulated & Made in Wales… (30ml)

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Thirty adult female Wistar rats divided into three groups were used in this study; the first group was sham-operated, while the second and third groups were ovariectomized. The first and second groups were injected with olive oil while the third group was injected with estradiol dipropionate daily for three months, after that; hormonal assay for T3, T4, TSH and specimens of the thyroid were taken and processed to be examined by light and electron microscopy. The results of this study revealed that serum levels of T3 and T4 decreased in ovariectomized animals and significantly increased after estradiol treatment, while TSH increased in ovariectomized animals and decreased with estradiol treatment. Histological and morphometric study in ovariectomized group revealed marked accumulation of colloid in follicular lumens with decreased epithelial height in addition to increased connective tissue amount. After estradiol treatment the follicles became smaller in size, having small amount of colloid with increased epithelial height in addition to decreased connective tissue content. Ultrastructural study supported these results in addition to the presence of large amount of intracytoplasmic colloid vesicles after estradiol treatment. Because it contains free iodine, Lugol's solution at 2% or 5% concentration without dilution is irritating and destructive to mucosa, such as the lining of the esophagus and stomach. Doses of 10 mL of undiluted 5% solution have been reported to cause gastric lesions when used in endoscopy. [20] The LD50 for 5% Iodine is 14,000mg/kg (14 g/kg) in rats, and 22,000mg/kg (22 g/kg) in mice. [21] During colposcopy, Lugol's iodine is applied to the vagina and cervix. Normal vaginal tissue stains brown due to its high glycogen content, while tissue suspicious for cancer does not stain, and thus appears pale compared to the surrounding tissue. Biopsy of suspicious tissue can then be performed. This is called a Schiller's test.

D1 converts inactive T4 to active T3 throughout the body, but D1 is not a significant determinant of pituitary T4 to T3 conversion, which is controlled by D2 (1,7,10). D1 but not D2 is suppressed and down-regulated (decreasing T4 to T3 conversion) in response to physiologic and emotional stress (11-22); depression (23-45); dieting (46-51); weight gain and leptin resistance (47-91); insulin resistance, obesity and diabetes (91-99); inflammation from autoimmune disease or systemic illness (11,100,102-115); chronic fatigue syndrome and fibromyalgia (121-125); chronic pain (116-120); and exposure to toxins and plastics (126-134). In the presences of such conditions there are reduced tissue levels of active thyroid in all tissues except the pituitary. The reduced thyroid tissue levels with these conditions is often quoted as a beneficial response that lowers metabolism and thus does not require treatment, but there is no evidence to support such a stance while there is significant evidence demonstrating it is a detrimental response (135-142).It can be used as a cell stain, making the cell nuclei more visible and for preserving phytoplankton samples. T. Uchida, H. Goto, T. Kasai, K. Komiya, K. Takeno, H. Abe, N. Shigihara, J. Sato, A. Honda, T. Mita, A. Kanazawa, Y. Fujitani, H. Watada, Therapeutic effectiveness of potassium iodine in drug-naive patients with Graves’ disease: a single-center experience. Endocrine 47(2), 506–511 (2014). https://doi.org/10.1007/s12020-014-0171-8

Also find molybdenum v helpful when toxic. I use Chem Defense by Source Naturals. Has B2 and reduced glutathione in it too. Lugol’s iodine was introduced in 1829, tincture of iodine in 1908 and finally povidone iodine PVP-I in 1955 (brand name: Betadine). Can I use Betadine everyday? In addition, D1 activity is also lower in females (143,144), making women more prone to tissue hypothyroidism, with resultant depression, fatigue, fibromyalgia, chronic fatigue syndrome, and obesity despite having normal TSH levels. R.E. Goldsmith, M.L. Eisele, The effect of iodide on the release of thyroid hormone in hyperthyroidism. Clin. Endocr. 15, 864 (1955)T. Yabuta, Y. Ito, M. Hirokawa, M. Fukushima, H. Inoue, C. Tomoda, T. Higashiyama, M. Kihara, T. Uruno, Y. Takamura, K. Kobayashi, A. Miya, F. Matsuzuka, A. Miyauchi, Preoperative administration of excess iodide increases thyroid volume of patients with Graves’ disease. Endocr. J. 56(3), 371–375 (2009) I think the 3-day salt-loading rule sounds like wise advice, but I still need to read Brownstein's "Salt Your Way To Health" before deciding about how I choose to use the protocol. I am very toxic, and salt definitely helps. I'm reluctant to limit it to three days at a time, because even when I pulse, I'm still getting a lot of unpleasant side-effects, and they very definitely ease with my pink Himalayan salt or my other organic sea-salt.

Meanwhile, low literacy and health literacy contributed to limited parental understanding of his condition, treatment rationale, careful administration, and monitoring of medications. Robbertz et al. insightfully examine the cultural issues influencing rural Kenyan mothers' and community leaders’ health literacy and response to childhood illness. Many of those interviewed properly identified illness in their children, though some, influenced by strong religious and cultural beliefs, attributed abnormal symptoms to “bewitchment.” In describing the response to childhood illness, many preferred traditional healers and chemists, saving medical professionals for severe illness. They also cite the often-confusing experience of mothers who receive advice from multiple incongruent community sources. The authors conclude that balancing medical advice and cultural norms is an important part of improving parental health literacy and health care delivery to their children [ 12]. Pulsing the iodine (taking every two days), taking milk thistle for liver support, and the salt loading protocol as described by Stephanie Buist ND (in her useful and informative Iodine Supplementation guide) was useful. From her guide: Taking anything you're deficient in does NOT reduce your ability to absorb it. That implies that receptors switch off due to over-exposure. I fail to see how that could be true of any vital substance. It sounds to me like yet another anti-natural medicine paper designed to put health professionals and patients off trying supplementing iodine.Effects of chronic estradiol treatment on the thyroid gland structure and function of ovariectomized rats The above uses and effects are consequences of the fact that the solution is a source of effectively free elemental iodine, which is readily generated from the equilibrium between elemental iodine molecules and polyiodide ions in the solution. Health Leads makes Lugol's solution based on an American formulation: Lugol’s contains iodine (I) and potassium iodide (KI). For a 1000ml (1 quart) amount: 44g (1.5oz) of iodine and 88g (3 oz) of potassium iodide are added to distilled water and when dissolved this is topped up to make 1000ml of solution.

Before taking this medication, tell your doctor or pharmacist if you are allergic to iodine or potassium iodide; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Some cases of subcutaneous phycomycosis are self-limiting [ 4]. Guidelines for management of cases that do not resolve on their own are not clear. Itraconazole is the most commonly reported effective treatment. Amphotericin B, ketoconazole, voriconazole, and posaconazole have also been reported [ 5]. Treatment with surgical resection alone is controversial due to risk of further spread of the infection. Many cases of subcutaneous phycomycosis treated surgically ultimately need antifungal therapy [ 6].J. Calissendorff, H. Falhammar, Rescue pre-operative treatment with Lugol’s solution in uncontrolled Graves’ disease. Endocr. Connect. 6(4), 200–205 (2017). https://doi.org/10.1530/EC-17-0025