Cumlaude CLX Vaginal Egg Lab - Protective, Soothing and Rebalancing Action for Intimate Zone, with Hyaluronic Acid - 10 Units

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Full Title of Study: “Evaluation of the Efficacy of Chlorhexidine Use During the First Trimester as a Regulator of Vaginal Microbiota in Reducing Preterm Birth” Study Type Statistical analysis Continuous variables were presented as mean and standard deviations (SD), median and interquartile range (IQR), while categorical variables were presented as absolute numbers and relative frequencies. Characteristics between both cohorts were compared by mean of Mann- Whitney and Fisher tests. Finally, to assess the validity of results and ensure consistency an additional multivariable analysis was performed adjusting for clinical parameters, to evaluate the odds ratio (OR) of the different determinants in the prediction of preterm birth. Finally, preterm birth incidence was calculated for specific groups selected according to the multivariable analysis result. Statistical analysis and graphs were done using Graph Pad Prism®, Mac version 9.0.1, and Stat Plus® Mac Pro version 8.0.1.s. Permissions were obtained from La Fe hospital review board and from the Valencian Autonomic Government health authorities (reference: PLUVA, date 4-2-2021). Written informed consent was retrieved to participate in the study. The authors report no conflicts of interest.

Clinical implications of the study: The clinical implications of our project would be to counteract the effect of pathogenic bacteria from the beginning of pregnancy (outside the teratogenic period) with the administration of the CLX ovules and thus enhance the action of the normal vaginal microbiota in the pregnant patient, since the glycogen available due to hormonal action favours the growth and development of lactobacillus, responsible for its protective activity against pathogens during pregnancy. Sample size: The approximate number of births per year in Spain is 370,000. The minimum number of patients to be recruited would be 400 with a 95% confidence interval. Patients were recruited as they attended the consultation where the PI and/or collaborators were present. Variables:– maternal age,– parity,– Gestational age (GA) at examination in weeks,– GA at delivery in weeks,– Interval between ultrasound and delivery,– Birth weight (BW), BW centile,– fetal gender,– onset of labor (elective cesarean section, induction of labor and spontaneous onset of labor),– mode of delivery (cesarean section for abnormal cardiotocography, failure to progress or elective, assisted delivery and spontaneous delivery),– Apgar scores at 5 minutes,– neonatal cord arterial hydrogen potential( pH)– Newborn destination: ward, neonatal, neonatal intensive care unit– Type of event triggering preterm birth:Premature rupture of membranes /Uterine dynamics + cervical modifications Statistical analysis Continuous variables were presented as mean and standard deviations (SD), median and interquartile range (IQR), while categorical variables were presented as absolute numbers and relative frequencies. Characteristics between both cohorts were compared by mean of Mann- Whitney and Fisher tests. Finally, to assess the validity of results and ensure consistency an additional multivariable analysis was performed adjusting for clinical parameters, to evaluate the odds ratio (OR) of the different determinants in the prediction of preterm birth. Finally, preterm birth incidence was calculated for specific groups selected according to the multivariable analysis result. Statistical analysis and graphs were done using Graph Pad Prism®, Mac version 9.0.1, and Stat Plus® Mac Pro version 8.0.1.s. Permissions were obtained from La Fe hospital review board and from the Valencian Autonomic Government health authorities (reference: PLUVA, date 4-2-2021). Written informed consent was retrieved to participate in the study. The authors report no conflicts of interest. Quality control: All analyses were performed on a single sample of patients who met the selection criteria and who had all the information required for the variables to be analysed. In cases where it was not possible to obtain this information, the following were excluded from the study Interventions Finally, preterm birth incidence was calculated for specific groups selected according to the multivariable analysis result. Pe viitor de cate ori veti lua antibiotic folositi ovule antimicotice si ar fi bine sa luati si iumostimulatoare, mai ales in peiroadele stresante. Este posibil sa va ajute: Ginexid Ovule - FarmaDerma (de la FarmaDerma) The pregnant women were then followed up until the end of pregnancy and compared with a cohort of patients who had not received any treatment.Statistical analysis Continuous variables were presented as mean and standard deviations (SD), median and interquartile range (IQR), while categorical variables were presented as absolute numbers and relative frequencies. Ginexid ovule este dedicat igienei intime; are efect emolient si protector prin restabilirea balantei fiziologice. Finally, to assess the validity of results and ensure consistency an additional multivariable analysis was performed adjusting for clinical parameters, to evaluate the odds ratio (OR) of the different determinants in the prediction of preterm birth. Leitich H, Kiss H. Asymptomatic bacterial vaginosis and intermediate flora as risk factors for adverse pregnancy outcome. Best Pract Res Clin Obstet Gynaecol. 2007 Jun;21(3):375-90. doi: 10.1016/j.bpobgyn.2006.12.005. Epub 2007 Jan 22. Participants were recruited at the routine first trimester consultation. All patients underwent an initial ultrasound examination between 6+0 and 15+6 weeks gestation, including assessment of embryo/fetus vitality.

Registra una identificación única que se utiliza para generar datos estadísticos acerca de cómo utiliza el visitante el sitio web. All data related to delivery were collected, as well as any events related to preterm delivery, such as onset of contractions, cervical shortening and premature rupture of membranes, regardless of final gestational age at delivery. Avand la baza ingrediente naturale si clorhexidina , Gama Ginexid a fost creata pentru a proteja eficient prin sustinerea mecanismelor naturale de aparare ( mentinerea aciditatii vaginale ) .Type of event triggering preterm birth:Premature rupture of membranes /Uterine dynamics + cervical modifications courier, είτε με την υπηρεσία Box Now, μπορείτε να χρησιμοποιήσετε την υπηρεσία Box Now ώστε να ολοκληρώσετε την αποστολή προς εμάς από την κοντινότερη θυρίδα σας. Taninele continute in extractul de Hamamelis au actiune antiinflamatorie si vasoconstrictoare; asigura o senzatie de prospetime a mucoaselor si tegumentelor. Hamamelis are si actiune moderata antiinfectioasa.

Extractul de Hamamelis si musetel protejeaza mucoasa vaginala si reduc inflamatia vaginului. Mai contine clorhexidina si vitamina E. MacIntyre DA, Chandiramani M, Lee YS, Kindinger L, Smith A, Angelopoulos N, Lehne B, Arulkumaran S, Brown R, Teoh TG, Holmes E, Nicoholson JK, Marchesi JR, Bennett PR. The vaginal microbiome during pregnancy and the postpartum period in a European population. Sci Rep. 2015 Mar 11;5:8988. doi: 10.1038/srep08988. Efectul tonic si revigorant al extractului de Hamamelis il recomanda pentru utilizarea in zonele sensibile si delicate. In cazul dumneavoastra, daca nu mai aveti mancarimi si secretii colorate (alb branzos, galben sau gri),urmati un tratament de 7 zile cu Zenella (1 comprimat dimineata, unul seara), apoi asteptati cateva zile si refaceti analizele de secretie vaginala. Este posibil sa va fi vindecat, dar secretia vaginala sa nu fie inca de consistenta si aspect normale din cauza afectiunilor prelungite. Antiseptic treatment aimed at reducing possible bacterial overgrowth consisted of 10 days (1 box) of CLX vaginal ovules (CLX digluconate 0.2%) always starting between 9+0 and 16+0 weeks.Partenerul dumneavoastra a facut candidoza ca urmare a tratamentului cu Ciprofloxacina, poate lua fluconazol 150 mg, doza unica, cu repetare peste 7 zile. Poate aplica si crema pe baza de clotrimazol. In perioada tratamentului va trebui sa va protejati cu prezervativ. Romero R, Hassan SS, Gajer P, Tarca AL, Fadrosh DW, Nikita L, Galuppi M, Lamont RF, Chaemsaithong P, Miranda J, Chaiworapongsa T, Ravel J. The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women. Microbiome. 2014 Feb 3;2(1):4. doi: 10.1186/2049-2618-2-4. Erratum In: Microbiome. 2014 Apr 15;2(1):10. Box Now κοστίζει 2,30€ για παραγγελίες με μέγιστο βάρος 20 κιλά και διαστάσεις έως 62 x 45 x 36 cm. Ginexid consta intr-o serie de produse concepute special pentru a intampina nevoile femeilor in variate situatii si in diferite etape ale vietii . Statistical analysis and graphs were done using Graph Pad Prism®, Mac version 9.0.1, and Stat Plus® Mac Pro version 8.0.1.s.