Niacyna B3 w leczeniu

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Katzung, Bertram G. (2006). Basic and clinical pharmacology. New York: McGraw-Hill Medical Publishing Division. ISBN 978-0-07-145153-6. Landray MJ, Haynes R, Hopewell JC, Parish S, Aung T, etal. (July 2014). "Effects of extended-release niacin with laropiprant in high-risk patients". N. Engl. J. Med. 371 (3): 203–12. doi: 10.1056/NEJMoa1300955. PMID 25014686. S2CID 23548060. Archived from the original on 29 June 2020 . Retrieved 27 June 2020. The mechanism behind niacin increasing HDL-C is not totally understood, but seems to occur in various ways. Niacin increases apolipoprotein A1 levels by inhibiting the breakdown of this protein, which is a component of HDL-C. [54] [55] It also inhibits HDL-C hepatic uptake by suppressing production of the cholesterol ester transfer protein (CETP) gene. [47] It stimulates the ABCA1 transporter in monocytes and macrophages and upregulates peroxisome proliferator-activated receptor gamma, resulting in reverse cholesterol transport. [56] Combined with statins [ edit ]

Niacyna przyjmowana w celach terapeutycznych powinna być wprowadzana do ustroju stopniowo, aby zapobiec wystąpieniu niepożądanych działań. Activating HCA 2 has effects other than lowering serum cholesterol and triglyceride concentrations: antioxidative, anti-inflammatory, antithrombotic, improved endothelial function and plaque stability, all of which counter development and progression of atherosclerosis. [73] [74] Alcohol. Taking niacin with alcohol might increase the risk of liver damage and worsen niacin side effects, such as flushing and itching.Philip P. Barter Philip P., Options for therapeutic intervention: how effective are the different agents?, „European Heart Journal Supplements”, 8 (suppl_F), 2006, F47–F53, DOI: 10.1093/eurheartj/sul041 ( ang.). Nadmiar niektórych substancji może być tak samo groźny, jak ich niedobór. Właśnie tak jest z cenną niacyną. Witamina B 3 (witamina PP) – wspólna nazwa na określenie dwóch związków: kwasu nikotynowego (niacyny, czyli kwasu 3-pirydyno karboksylowego, pochodnej pirydyny) i jego amidu (nikotynamidu), które dla człowieka są witaminą.

Tolerable Upper Intake Levels For Vitamins And Minerals" (PDF). European Food Safety Authority. 2006. Archived (PDF) from the original on 16 March 2016 . Retrieved 9 March 2016. In 1942, when flour enrichment with nicotinic acid began, a headline in the popular press said "Tobacco in Your Bread." In response, the Council on Foods and Nutrition of the American Medical Association approved of the Food and Nutrition Board's new names niacin and niacin amide for use primarily by non-scientists. It was thought appropriate to choose a name to dissociate nicotinic acid from nicotine, to avoid the perception that vitamins or niacin-rich food contains nicotine, or that cigarettes contain vitamins. The resulting name niacin was derived from nicotinic acid + vitam in. [108] [109]Nicotinamide (niacinamide) is used to treat niacin deficiency because it does not cause the flushing adverse reaction seen with niacin. Nicotinamide may be toxic to the liver at doses exceeding 3 g/day for adults. [88] Flavonoids (incl. 7,8-DHF, 8-prenylnaringenin, apigenin, baicalein, baicalin, biochanin A, calycosin, catechin, daidzein, daidzin, ECG, EGCG, epicatechin, equol, formononetin, glabrene, glabridin, genistein, genistin, glycitein, kaempferol, liquiritigenin, mirificin, myricetin, naringenin, penduletin, pinocembrin, prunetin, puerarin, quercetin, tectoridin, tectorigenin) Niacin and Niacin Amide". Journal of the American Medical Association. 118 (10): 819. 7 March 1942. doi: 10.1001/jama.1942.02830100049011. a b Health Canada (20 July 2005). "Dietary Reference Intakes". Government of Canada. Archived from the original on 14 June 2018 . Retrieved 20 June 2018.