BEE VENOM CREAM - 30ml FAST RELIEF MUSCLE JOINT PAIN VERY EFFECTIVE

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Certain methods of bee-venom therapy, including acupuncture, can lead to side effects, such as pain, swelling, and redness. Keneth Iceland Kasozi 1,2 * Gniewko Niedbała 3 * Mohammed Alqarni 4 Gerald Zirintunda 5 Fred Ssempijja 6 Simon Peter Musinguzi 2 Ibe Michael Usman 6 Kevin Matama 7 Helal F. Hetta 8 Ngala Elvis Mbiydzenyuy 9 Gaber El-Saber Batiha 10 * Amany Magdy Beshbishy 11 Susan Christina Welburn 1,12 * Gu H, Han SM, Park K-K. therapeutic effects of apamin as a bee venom component for non-neoplastic disease. Toxins. (2020) 12:195. doi: 10.3390/toxins12030195 Son DJ, Kang J, Kim TJ, Song HS, Sung KJ, Yun DY, et al. Melittin, a major bioactive component of bee venom toxin, inhibits PDGF receptor beta-tyrosine phosphorylation and downstream intracellular signal transduction in rat aortic vascular smooth muscle cells. J Toxicol Environm Health Part A. (2007) 70:1350–5. doi: 10.1080/15287390701428689

Marichal T, Starkl P, Reber LL, Kalesnikoff J, Oettgen HC, Tsai M, et al. A beneficial role for immunoglobulin E in host defense against honeybee venom. Immunity. (2013) 39:963–75. doi: 10.1016/j.immuni.2013.10.005 Ji Y, Ma Z, Peppelenbosch MP, Pan Q. Potential association between COVID-19 mortality and health-care resource availability. Lancet GlobHealth. (2020) 8:e480. doi: 10.1016/S2214-109X(20)30068-1Of particular note, a review of 145 studies on the side effects of bee-venom therapy found that an average of 29% of people experienced adverse effects — ranging from mild to severe — after treatment ( 28). Additionally, it contains phospholipase A2, an enzyme and major allergen that causes inflammation and cell damage. Nevertheless, according to some research, the enzyme may also have anti-inflammatory and immunoprotective effects ( 4, 5). Chirumbolo S, Zanoni G, Ortolani R, Vella A. In vitro biphasic effect of honey bee venom on basophils from screened healthy blood donors. Allergy Asthma Immunol Res. (2011) 3:58. doi: 10.4168/aair.2011.3.1.58 Bee venom phospholipase 2 ( bvPLA2) is the main allergen in BV and stimulates the innate immune system by binding to pattern-recognition receptors (PRRs), e.g., Toll-like receptors that recognize pathogen-associated molecular patterns (PAMPs), triggering a type 2 immune response. bvPLA2 induces T-helper cell-type reactions and group 2 innate lymphoid cells (ILC2s) facilitated through the enzyme-aided cleavage of membrane phospholipids and secretion of IL-33. bvPLA2 also induces the production of IgE shown to be protective in mice from future allergic/immunologic reactions [in the case of a lethal dose of BV ( 70)]. PLA2 plays a vital role in host defense in Th2 differentiation, ILC2 activation, immunoglobulin production, membrane remodeling, and anti-inflammatory reactions ( 44, 70). BV has been explored in cancer ( 111, 112); melittin is considered cytolytic but non-specific. Melittin can break down the membrane lipid bilayer and exhibits toxicity when injected intravenously ( 113). APi M has the ability to suppress tumor growth in breast, liver, prostate, and lung cancer cells ( 111, 112). In vitro and in vivo studies show that melittin can suppress growth of cancerous cells by inhibiting NF-κB signaling and activating caspase 3 and 9 pathways. Inhibition of hepatocellular carcinoma cell motility was observed in vitro and in vivo by suppression of Rac1-dependent pathways ( 114). Anti-inflammatory Potential

Abdela N, Jilo K. Bee venom and its therapeutic values: a review. Adv Life Sci Technol. (2016) 44:18–22. Available online at: https://www.iiste.org/Journals/index.php/ALST/article/view/30404/31249 Aqua (Water), Cyclopentasiloxane, Glycerin, Butyrospermum Parkii (Shea Butter), Oryza Sativa (Rice) Germ Oil, Ethylhexyldodecanol, Cetyl Alcohol, Dimethicone, Caprylic/ Capric Triglyceride, Cyclohexasiloxane, Glyceryl Dibehenate, Polysilicone-11, Cetearyl Alcohol, Gryceryl Stearate, PEG-75 Stearate, Phenoxyethanol, Tribehenin, Steareth-20, Alcohol, Glyceryl Behenate, Ascorbyl Tetraisopalmitate, Ceteth-20, Ectoin, Lecithin, Polyacrylamide, Xanthan Gum, Capsicum Annuum Meristem Cell Culture, Parfum (Fragrance), Ethylhexylglycerin, Sodium Hyaluronate, Tocopherol, C13-14 Isoparaffin, Disodium EDTA, Geranylgeranylisopropanol, Helianthus Annuus (Sunflower) Seed Oil, Chlorhexidine Digluconate, Laureth-7, Triethanolamine, Citric Acid, Alpha-Isomethyl Ionone, N-Hydroxysuccinimide, Hydroxycitronellal, Potassium Sorbate, Limonene, Citronellol, Sodium Benzoate, Beta-Carotene, Daucus Carota Sativa (Carrot) Root Extract, Daucus Carota Sativa (Carrot) Seed Oil, Cyclotetrapeptide-24 Aminocyclohexane Carboxylate, Chrysin, Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide, Ascorbyl Palmitate, Bee Venom. It has been shown to have anti-inflammatory properties, may benefit skin health, and can possibly help treat symptoms related to various health conditions, such as rheumatoid arthritis and chronic pain.Another study in 100 people with RA showed that combining bee-sting therapy with traditional medications like Methotrexate, Sulfasalazine, and Meloxicam was more effective at reducing pain and joint swelling than treatment with the traditional medication alone ( 13). Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. (2020) 109:102433. doi: 10.1016/j.jaut.2020.102433 Owen MD, Pfaff LA. Melittin synthesis in the venom system of the honey bee (Apis mellifera L). Toxicon. (1995) 33:1181–8. doi: 10.1016/0041-0101(95)00054-P