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Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 1995;274:1049-57. View abstract. Vitamin B-12 deficiency is not common in the U.S. However, people who follow a vegetarian or vegan diet might be prone to deficiency because plant foods don't contain vitamin B-12. Older adults and people with digestive tract conditions that affect absorption of nutrients also are susceptible to vitamin B-12 deficiency. Batu, A. T., Toe, T., Pe, H., and Nyunt, K. K. A prophylactic trial of iron and folic acid supplements in pregnant Burmese women. Isr.J.Med.Sci. 1976;12(12):1410-1417. View abstract. Colman, N., Larsen, J. V., Barker, M., Barker, E. A., Green, R., and Metz, J. Prevention of folate deficiency by food fortification. III. Effect in pregnant subjects of varying amounts of added folic acid. Am.J Clin.Nutr 1975;28(5):465-470. View abstract. Weak and brittle bones (osteoporosis). Taking vitamin B12 and folic acid by mouth, with or without vitamin B6, doesn't seem to reduce fractures in older people with osteoporosis.

Kwok, T., Tang, C., Woo, J., Lai, W. K., Law, L. K., and Pang, C. P. Randomized trial of the effect of supplementation on the cognitive function of older people with subnormal cobalamin levels. Int J Geriatr.Psychiatry 1998;13(9):611-616. View abstract.Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. View abstract. Blanchette, V., Bell, E., Nahmias, C., Garnett, S., Milner, R., and Zipursky, A. A randomized control trial of vitamin E therapy in the prevention of anemia in low birth weight (LBW) infants. Pediatr.Res. 1980;14:591. Giuliano, A. R., Papenfuss, M., Nour, M., Canfield, L. M., Schneider, A., and Hatch, K. Antioxidant nutrients: associations with persistent human papillomavirus infection. Cancer Epidemiol.Biomarkers Prev. 1997;6(11):917-923. View abstract. Sommer, B. R., Hoff, A. L., and Costa, M. Folic acid supplementation in dementia: a preliminary report. J Geriatr.Psychiatry Neurol. 2003;16(3):156-159. View abstract. Jacques, P. F., Selhub, J., Bostom, A. G., Wilson, P. W., and Rosenberg, I. H. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N.Engl.J Med 5-13-1999;340(19):1449-1454. View abstract.

Thu, B. D., Schultink, W., Dillon, D., Gross, R., Leswara, N. D., and Khoi, H. H. Effect of daily and weekly micronutrient supplementation on micronutrient deficiencies and growth in young Vietnamese children. Am J Clin Nutr 1999;69(1):80-86. View abstract. Reinken, L. and Kurz, R. [The treatment of anemia due to iron-deficiency with iron combined with vitamins (author's transl)]. Klin.Padiatr. 1978;190(2):163-167. View abstract. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Neal, D. E., Hamdy, F. C., Smith, A. D., and Martin, R. M. Circulating folate, vitamin B12, homocysteine, vitamin B12 transport proteins, and risk of prostate cancer: a case-control study, systematic review, and meta-analysis. Cancer Epidemiol.Biomarkers Prev. 2010;19(6):1632-1642. View abstract. Duthie SJ, Whalley LJ, Collins AR, et al. Homocysteine, B vitamin status, and cognitive function in the elderly. Am J Clin Nutr 2002;75:908-13.. View abstract. Beaulieu AJ, Gohh RY, Han H, et al. Enhanced reduction of fasting total homocysteine levels with supraphysiological versus standard multivitamin dose folic acid supplementation in renal transplant recipients. Arterioscler Thromb Vasc Biol 1999;19:2918-21. View abstract.Fairfield KM. Vitamin supplementation in disease prevention. https://www.uptodate.com/contents/search. Accessed Jan. 9, 2021. Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Advertising & Sponsorship