Apigenin 100mg x 90 Capsules - Third Party Tested Over 98% - Natural Apigenin Supplement Vitality Pro

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Apigenin has striking effects against cancerous cells while remaining non-toxic to normal cells. Apigenin is a potentially effective therapy against different types of cancer. Careful examination of the available data indicates that it is unlikely that dietary ingestion of apigenin-containing plant materials–even those with very high levels such as parsley–will lead to biologically meaningful effects on cells through the vascular route without heroic levels of intake. This does not completely exclude the possibility that local high concentrations of apigenin acting directly from the gastrointestinal lumen could affect intestinal tissues in the gut wall, including primary tumors. The potential for locally efficaceous concentrations could be examined by local tissue measurements of apigenin uptake, perhaps using the microdialysis approach that we introduced for measuring metabolites in solid tumors ( Blay et al., 1997).

As discussed in the previous section, Apigenin may increase testosterone and reduce cortisol levels, which creates an anabolic (muscle growth-promoting) environment in the body. In mice and rats recovering from strokes, apigenin glucopyranoside (a subtype of apigenin) improved neurological outcomes and reduced brain cell death [ 35]. Reducing Blood Sugar Levels Two clinical trials testing an apigenin-containing extract on the same population and some animal and cell-based research are insufficient to support the use of apigenin for anxiety and depression until more clinical research is conducted. 2) Skin HealthApigenin is one of the most renowned phenolic compounds with many beneficial properties, and it is available in nutraceutical formulations and dietary supplements. In mice, topical apigenin improved skin permeability barrier function by promoting skin cell growth and the production of fatty molecules and antimicrobial proteins. This suggests it may help with conditions characterized by permeability barrier dysfunction such as atopic dermatitis [ 7].

Apigenin has l ow intrinsic toxicity and is generally safe . Dietary food and supplements containing apigenin have not been associated with debilitating health impacts. Apigenin sleep and relaxation benefits are largely accredited to its ability to reduce feelings of anxiety and increase feelings of sedation. This could largely be due to its ability to reduce cortisol levels ( 7). Using a circulating concentration for efficacy of 1–5μmol/L as the target, we evaluated data from both human and rodent pharmacokinetic studies to determine if a therapeutic concentration would be feasible. We find that oral intake of dietary materials would require heroic ingestion amounts and is not feasible. However, use of supplements of semi-purified apigenin in capsule form could reach target blood levels using amounts that are within the range currently acceptable for other supplements and medications. Modified formulations or parenteral injection are suitable but may not be necessary. Safety is an important aspect of dietary components. In general, dietary plants containing flavonoids have not been associated with negative health impact, but they are rather considered to be beneficial. Apigenin is known for its low toxicity [ 9, 11, 43, 44]. Evidence has also shown that a flavonoid-rich diet is inversely associated with cancer risk [ 45– 50]. Therefore, the consumption of flavonoids has been assumed to be safe.Apigenin also possesses anti-diabetic properties due to its capacity to lower blood glucose levels and increase insulin secretion.