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Drug Addiction Research and the Health of Women – pg. 33–52" (PDF). Archived from the original (PDF) on August 22, 2008 . Retrieved March 21, 2010. PAPADAKI, P. G. KRITIKOS, S. P. "The history of the poppy and of opium and their expansion in antiquity in the eastern Mediterranean area". Unodc.org. UNODC- Bulletin on Narcotics – 1967 Issue 4 – 002 . Retrieved May 31, 2022. {{ cite web}}: CS1 maint: multiple names: authors list ( link)

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Ballantyne, Jane C., and Jianren Mao. "Opioid Therapy For Chronic Pain". New England Journal of Medicine 349.20 (n.d.): 1943–1953. SocINDEX with Full Text. Web. November 3, 2011. In June 2007, the council launched a "Poppy for Medicines" project that provides a technical blueprint for the implementation of an integrated control system within Afghan village-based poppy for medicine projects: the idea promotes the economic diversification by redirecting proceeds from the legal cultivation of poppy and production of poppy-based medicines. [140] There has been criticism of the Senlis report findings by Macfarlan Smith, who argue that though they produce morphine in Europe, they were never asked to contribute to the report. [141] Cultivation in the UK [ edit ] Poppy seeds are a common and flavorsome topping for breads and cakes. One gram of poppy seeds contains up to 33 micrograms of morphine and 14 micrograms of codeine, and the Substance Abuse and Mental Health Services Administration in the United States formerly mandated that all drug screening laboratories use a standard cutoff of 300 nanograms per milliliter in urine samples. A single poppy seed roll (0.76grams of seeds) usually did not produce a positive drug test, but a positive result was observed from eating two rolls. A slice of poppy seed cake containing nearly five grams of seeds per slice produced positive results for 24 hours. Such results are viewed as false positive indications of drug use and were the basis of a legal defense. [116] [117] On November 30, 1998, the standard cutoff was increased to 2000 nanograms (two micrograms) per milliliter. [118] Confirmation by gas chromatography-mass spectrometry will distinguish amongst opium and variants including poppy seeds, heroin, and morphine and codeine pharmaceuticals by measuring the morphine:codeine ratio and looking for the presence of noscapine and acetylcodeine, the latter of which is only found in illicitly produced heroin, and heroin metabolites such as 6-monoacetylmorphine. [119] Harvesting and processing [ edit ] Harvesting opium Pablo Bartholomew (1996). "Opium for the masses: photo essay on cultivation of opium in India". Archived from the original on July 1, 2007 . Retrieved June 15, 2007. John Rennie (March 26, 2007). "When a woman ruled Chinatown". Tower Hamlets Newsletter. Archived from the original on February 10, 2010 . Retrieved May 12, 2007.Opium – Poppy Cultivation, Morphine and Heroin Manufacture". Erowid.org . Retrieved January 25, 2017. Nye, Gideon (1873). The morning of my life in China: comprising an outline of the history of foreign intercourse from the last year of the regime of honorable East India Company, 1833, to the imprisonment of the foreign community in 1839. W. Travis Hanes III; Frank Sanello (February 1, 2004). The Opium Wars: The Addiction of One Empire and the Corruption of Another. Sourcebooks. pp.88–. ISBN 978-1-4022-5205-1. Peter Ward Fay (November 9, 2000). The Opium War, 1840–1842: Barbarians in the Celestial Empire in the Early Part of the Nineteenth Century and the War by which They Forced Her Gates Ajar. Univ of North Carolina Press. pp.290–. ISBN 978-0-8078-6136-3. Santella, Thomas M.; Triggle, D. J. (2009). Opium. Facts On File, Incorporated. p.8. ISBN 9781438102139.

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Map showing the amount of opium produced in China in 1908: The quote "We English, by the policy we have pursued, are morally responsible for every acre of land in China which is withdrawn from the cultivation of grain and devoted to that of the poppy; so that the fact of the growth of the drug in China ought only to increase our sense of responsibility." is by Lord Justice Fry. Ladenburg, Thomas (1974). "Chapter 1, The French in Indochina" (PDF). University of Houston. Archived (PDF) from the original on March 1, 2023 . Retrieved March 21, 2023. Heroin, the first semi-synthetic opioid, was first synthesized in 1874, but was not pursued until its rediscovery in 1897 by Felix Hoffmann at the Bayer pharmaceutical company in Elberfeld, Germany. From 1898 to 1910 heroin was marketed as a non-addictive morphine substitute and cough medicine for children. Because the lethal dose of heroin was viewed as a hundred times greater than its effective dose, heroin was advertised as a safer alternative to other opioids. [104] By 1902, sales made up 5 percent of the company's profits, and "heroinism" had attracted media attention. [105] Oxycodone, a thebaine derivative similar to codeine, was introduced by Bayer in 1916 and promoted as a less-addictive analgesic. Preparations of the drug such as oxycodone with paracetamol and extended release oxycodone remain popular to this day. [ citation needed]Joyce A. Madancy (April 2004). "The Troublesome Legacy of Commissioner Lin" . Retrieved September 25, 2007. This section needs to be updated. Please help update this article to reflect recent events or newly available information. ( October 2022) Opium contains two main groups of alkaloids. Phenanthrenes such as morphine, codeine, and thebaine are the main psychoactive constituents. [150] Isoquinolines such as papaverine and noscapine have no significant central nervous system effects. Morphine is the most prevalent and important alkaloid in opium, consisting of 10–16 percent of the total, and is responsible for most of its harmful effects such as lung edema, respiratory difficulties, coma, or cardiac or respiratory collapse. Morphine binds to and activates mu opioid receptors in the brain, spinal cord, stomach and intestine. Regular use can lead to drug tolerance or physical dependence. Chronic opium addicts in 1906 China [48] consumed an average of eight grams of opium daily; opium addicts in modern Iran [151] are thought to consume about the same. a b c M J Brownstein (June 15, 1993). "A brief history of opiates, opioid peptides, and opioid receptors". Proceedings of the National Academy of Sciences of the United States of America. 90 (12): 5391–5393. Bibcode: 1993PNAS...90.5391B. doi: 10.1073/pnas.90.12.5391. PMC 46725. PMID 8390660. McCoy, Alfred W. The Politics of Heroin: CIA Complicity in the Global Drug Trade. New York: Lawrence Hill Books, 1991.

Opium – DrugWise Opium – DrugWise

Julius Berendes (1902). "De Materia Medica" (in German). Archived from the original on February 8, 2007 . Retrieved May 10, 2007. Before the 1920s, regulation in Britain was controlled by pharmacists. Pharmacists who were found to have prescribed opium for illegitimate uses and anyone found to have sold opium without proper qualifications would be prosecuted. [94] With the passing of the Rolleston Act in Britain in 1926, doctors were allowed to prescribe opiates such as morphine and heroin if they believed their patients demonstrated a medical need. Because addiction was viewed as a medical problem rather than an indulgence, doctors were permitted to allow patients to wean themselves off opiates rather than cutting off any opiate use altogether. [95] The passing of the Rolleston Act put the control of opium use in the hands of medical doctors instead of pharmacists. Later in the 20th century, addiction to opiates, especially heroin in young people, continued to rise and so the sale and prescription of opiates was limited to doctors in treatment centers. If these doctors were found to be prescribing opiates without just cause, then they could lose their license to practice or prescribe drugs. [95] A little of it, taken as much as a grain of ervum is a pain-easer, and a sleep-causer, and a digester...but being drank too much it hurts, making men lethargical, and it kills. Eventually, laudanum became readily available and extensively used by the 18th century in Europe, especially England. [33] Compared to other chemicals available to 18th century regular physicians, opium was a benign alternative to arsenic, mercury, or emetics, and it was remarkably successful in alleviating a wide range of ailments. Due to the constipation often produced by the consumption of opium, it was one of the most effective treatments for cholera, dysentery, and diarrhea. As a cough suppressant, opium was used to treat bronchitis, tuberculosis, and other respiratory illnesses. Opium was additionally prescribed for rheumatism and insomnia. [34] Medical textbooks even recommended its use by people in good health, to "optimize the internal equilibrium of the human body". [19] Opium prohibition in China began in 1729, yet was followed by nearly two centuries of increasing opium use. A massive destruction of opium by an emissary of the Chinese Daoguang Emperor in an attempt to stop opium smuggling by the British led to the First Opium War (1839–1842), in which Britain defeated China. After 1860, opium use continued to increase with widespread domestic production in China. By 1905, an estimated 25 percent of the male population were regular consumers of the drug. Recreational use of opium elsewhere in the world remained rare into late in the 19th century, as indicated by ambivalent reports of opium usage. [44] In 1906, 41,000 tons were produced, but because 39,000 tons of that year's opium were consumed in China, overall usage in the rest of the world was much lower. [48] These figures from 1906 have been criticized as overestimates. [49] A Chinese opium house; photographed in 1902El Zahrawi – Father Of Surgery". Archived from the original on September 27, 2007 . Retrieved May 4, 2007. Benjamin Pui-Nin Mo & E. Leong Way (October 1, 1966). "An Assessment Of Inhalation As A Mode Of Administration Of Heroin By Addicts". Journal of Pharmacology and Experimental Therapeutics. 154 (1): 142–151. PMID 5924312 . Retrieved June 6, 2007.