Lewitzka U, Severus E, Bauer R, Ritter P, Müller-Oerlinghausen B, Bauer M (2015) The suicide prevention effect of lithium: more than 20 years of evidence-a narrative review. Int J Bipolar Disord 3:32 Participants f Williams RSB, Cheng L, Mudge AW, Harwood AJ (2002) A common mechanism of action for three mood-stabilizing drugs. Nature 417:292–295 Reimann C, Birke M (2010) Geochemistry of European bottled water. Gebrüder Borntraeger Verlagsbuchhandlung: Stuttgart, Germany

You can ask your doctor for a referral to a psychologist or other mental health professional who uses Ohgami H, Terao T, Shiotsuki I, Ishii N, Iwata N (2009) Lithium levels in drinking water and risk of suicide. Br J Psychiatry 194:464–465 Dopierała E, Rybakowski JK (2015) Deprywacja snu jako metoda chronoterapii w leczeniu depresji. Psychiatr Pol 49(3):423–433 As you’ve seen in the previous section, one of the possible lithium orotate side effects, weight gain, is sometimes observed with long-term use. A study that included 1,206,174 men and women in Japan found an association between higher drinking water lithium concentrations and a lower rate of death during a given period. 7 When the researchers gave lithium to roundworms, a longer life span was observed. In a study involving fruit flies, lithium extended lifespan when administered throughout adulthood or later in life. 8Daunderer M (September 1982). "Lithium aspartate in drug dependence". Fortschr. Med. 100 (33): 1500–2. PMID 7129311. The article below will explore the effects of lithium on the brain, as well as its potential negative side effects, to help gauge its potential benefits as well as its risk factors for people suffering from anxiety. What is Lithium? Müller-Oerlinghausen B, Imiela M (June 1986). "Is lithium aspartate at low serum levels more effective than the usual lithium salts?". Nervenarzt. 57 (6): 370–3. PMID 3736729. Although motor symptom progression leads to disability in PD, cognitive impairment with progression to dementia has a greater negative impact on quality of life in PD than motor symptoms, occurs in the majority of PD patients and strongly predicts nursing home placement ( Aarsland et al., 2000; Schrag et al., 2000; Hely et al., 2008; Lawson et al., 2016). On average, it takes about 10 years for dementia to occur after PD diagnosis ( Aarsland and Kurz, 2010), which highlights the need for identification of cognition progression biomarkers that could be used in clinical trials to help identify therapies to slow cognitive decline even in early PD. Recently, our group identified FW progression in the DMN-T and nbM to reflect longitudinal cognitive decline in early PD from PPMI ( Guttuso et al., 2022). Thus, a therapy that slowed FW progression in the DMN-T and nbM in PD would imply that it may be able to slow long-term cognitive decline and prevent dementia. Our findings associating medium-dose lithium aspartate therapy with longitudinal reductions in DMN-T and nbM FW show promise towards these ends. Most notably, low-dose lithium seems to have a strong potential to help those suffering from depression. The Case for Treating Depression with Lithium

Nestel P, Bouis HE, Meenakshi JV, Pfeiffer W (2006) Biofortification of staple food crops. J Nutr 136:1064–1067 Soleimani M, Ghasemi N (2017) Lithium chloride can induce differentiation of human immortalized RenVm cells into dopaminergic neurons. Avicenna J Med Biotech 9(4):176–180

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