Vitamin K2-7 facilitates carboxylation of glutamate (Glu) residue present on growth arrest-specific protein 6 (Gas6) to γ-carboxyglutamate (Gla) leading to its activation, activated Gas6 binds to AXL receptor tyrosine kinase (AXL RTK) and initiates phosphoinositide 3-kinase/protein kinase B/BCL-2-associated death promoter protein (PI3K/AKT/BAD) signaling, BAD has an inhibitory effect on Caspase 3, this abrogates apoptosis and provides protection by K2-7 against β-amyloid (Aβ)-induced cytotoxicity.

Hence, the study confirms the protective role of vitamin K2 mediated by its antioxidant and anti-apoptotic properties ( Hadipour et al. Further, it was reported that MK-7 supplements at concentrations around recommended dietary allowance (RDA = 75 µg) ( Theuwissen et al. Matrix Gla protein (MGP) plays a key role in inhibition of vascular calcification; it has the potential to inhibit as well as to reverse the process of calcification. Proinflammatory cytokines like TNFα and IL-1β are associated with peripheral neuropathy development through neuroinflammatory mechanisms ( Li QY. Yogurt Kplus group was reported to have the largest improvement of MGP carboxylation, however this effect was majorly attributed to the response in women.Arterial wall mineralization is mediated by bone matrix proteins that are produced by osteoblast-like cells ( Leopold, 2015). In this way, the vitamin obtained a carrier that further supports its absorption and the product got additional properties valuable to humans and their diet! Effect of Menaquinone(MK-7) Supplementation on Deppression Status, Fasting Blood Sugar and Serum Vitamin K Level in Patients with Polycystic Ovary Syndrome. Synthesis of DNA and contact-independent growth in several human cancers including hepatocellular carcinoma (HCC) can be enhanced when cyclin D1 is overexpressed ( Zhang et al.

Study of the Effect of Food Vitamin K2 Intake in Association with a Fermented Dairy Product on Patients Treated with Vitamin K Antagonist (VKA). enhanced carboxylation of matrix Gla protein (MGP) and osteocalcin (OC), while a decrease in the levels of circulating dephospho-uncarboxylayed MGP (dp-ucMGP) and uncarboxylated osteocalcin (ucOC) as well as in the ucOC:cOC ratio was observed. Undercarboxylated Osteocalcin: ExperimNatural dietary sources of Vitamin K2 MK-7 include eggs, yoghurt, natto (a Japanese fermented soybean product) and green leafy vegetables.

For synthesizing one molecule of vitamin K2-7, seven molecules of isopentenyl diphosphate (IPP), the building blocks of isoprenoid units, are required. Vitamin K was discovered in 1923 by a German scientist who named the vitamin as koagulationsvitamin due to its blood clotting abilities.During cell cycle, Cyclin D1 contributes to the G 1-S transformation by binding to CDK4 or CDK6 ( Masaki et al. A Phase 2, Double Blind, Randomized, Placebo-Controlled Clinical Trial to Investigate the Safety and Effects of Oral Vitamin K2 Supplementation in COVID-19. It was observed that decrease in dp-ucMGP was 17, 33 and 46% respectively indicating a dose dependent response by MK-7 supplementation. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).