Refer to the screening for Down’s syndrome, Edwards’ syndrome and Patau’s syndrome section of the FASP handbook for additional details. Numerator: number of women with higher chance results attending an appointment in ≤ 3 working days to discuss their results. The numerator and denominator exclude congenitally corrected transposition of the great arteries ( TGA). Denominator: number of samples for T21, T18, T13 screening received in the laboratory in the reporting period.

FA4 was introduced in 2020 to 2021. New KPIs are not published in the first year of data collection. This time is used to improve the data quality and completeness, by revising the definition, adding clarity and / or setting thresholds as required. After this time, we will review the data with the aim of publishing it from the following year. 2. Infectious diseases in pregnancy screening 2.1 KPI ID1: HIV coverage Where the provider has a pathway in place to offer the 20-week screening scan between 18 weeks plus 0 days and 23 weeks plus 0 days, this pathway must: Out of all screening services who submitted data (137 out of 139) 136 met the acceptable threshold of 90%, with 132 meeting the achievable threshold of 95% and 16 of them reporting performance of 100%.National performance of ST4b (see standard STC-S05) in Q1 was 68.4%, higher than the previous quarter. The trend graph below shows England ST4b performance since the KPI was first published in Q1 2019 to 2020. Thresholds have not yet been set for this KPI. FA4 was introduced in 2020 to 2021. New KPIs are not published in the first year of data collection. This time is used to improve the data quality and completeness, by revising the definition, adding clarity and / or setting thresholds as required. After this time we will review the data with the aim of publishing it from the following year. 2. Infectious diseases in pregnancy screening 2.1 KPI ID1: HIV coverage The proportion of QF-PCR test results reported in on or before 3 calendar days of sample receipt. Rationale There is no intention to publish FA3 by individual maternity service. We are reviewing the data with the aim of publishing it national in the future.

make sure women with a higher chance result following combined or quadruple screening are offered an appointment in ≤ 3 working days of the result being available to discuss the options of: This is one of the standards we had to renumber but you will remember it as the old FASP-S09. This revised standard will look at test turnaround times for QF-PCR testing only. National performance of NB2 (see standard NBS-S06) in Q4 was 2.4%, lower than the previous quarter. The trend graph below shows that England NB2 performance is above the acceptable threshold of 2%. NB2 is a KPI where a lower performance is better. In both FASP-S01 (coverage: T21/T18/T13 screening) and FASP-S02 (coverage: 20-week screening scan) we have made changes to the exclusion category. For women who present to service at at or after 20 weeks plus 6 days where the sonography department can offer a screening scan appointment and complete screening by 23 weeks plus 0 days.Identified babies are those with a confirmed diagnosis of one or more of the following serious cardiac anomalies occurring in isolation: make sure a local pathway is in place for women who need more information at the point of screening Denominator: total number of T21, T18, T13 screening samples received in the screening laboratory in the reporting period Denominator: number of samples received in the genomic laboratory in the reporting period where the indication for QF-PCR testing was: Screening for 11 physical conditions as part of the 20-week scan is offered to all pregnant women and takes place between 18⁺⁰ and 20⁺⁶ weeks of pregnancy. Scans can be completed up to 23⁺⁰ weeks of pregnancy. Conditions screened for

The eligibility criteria for entry into the first trimester screening programme is a fetal crown rump length ( CRL) measurement between 45.0mm and 84.0mm (11 weeks plus 2 days to 14 weeks plus 1 day of pregnancy). This standard provides assurance that screening is offered to everyone who is eligible and each individual who chooses to accept screening has a conclusive screening result. Definition Date standard last updated: April 2018 FASP-S05: test: turnaround time T21, T18, T13 screening Description

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This standard monitors the true detection of the screening tests. This standard provides assurance that the screening tests are performing at optimal levels. Definition Down’s syndrome (T21) combined test