a b c d Mochida GH (September 2009). "Genetics and biology of microcephaly and lissencephaly". Seminars in Pediatric Neurology. 16 (3): 120–6. doi: 10.1016/j.spen.2009.07.001. PMC 3565221. PMID 19778709. Hong SE, Shugart YY, Huang DT, Shahwan SA, Grant PE, Hourihane JO, Martin ND, Walsh CA (September 2000). "Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations". Nature Genetics. 26 (1): 93–6. doi: 10.1038/79246. PMID 10973257. S2CID 67748801. You can actually demonstrate why the wrinkles are better by taking a sheet of paper. It’s all about surface area. If you take two sheets of paper, laying them flat on a table, they both have the same surface area. Because you know, they’re the same.

Smooth brain memes have undergone various adaptations and variations, such as “my brain is too smooth” or “brain ain’t smooth,” creating a coping mechanism for those struggling with mental health issues. Variations And Spin-offs Smooth Brain Memes have become a form of self-expression and a way to shape and influence language and social norms. On the other hand, the term Smooth Brain is often used in a negative context. It is used to describe someone who is slow or stupid. It can also be used to describe someone who is unfunny or uncool. The term is often used as an insult to belittle someone’s intelligence or abilities. a b c Kato M, Dobyns WB (April 2003). "Lissencephaly and the molecular basis of neuronal migration". Human Molecular Genetics. 12 (1): R89–R96. doi: 10.1093/hmg/ddg086. PMID 12668601. DCX: DCX is located on the X chromosome. Since people assigned male at birth (AMAB) have one X chromosome and one Y chromosome, infants AMAB are more likely to be severely affected by this gene mutation that causes lissencephaly. Infants assigned female at birth (AFAB), who have two X chromosomes, with the same mutation usually have a milder version of the condition.We’ve all heard the grey matter mass hiding in our skulls called our “noodle” before. That’s probably because the brain, on the outside, looks kind of like a noodle wrapped and laid over itself, since its all wrinkly like that. But, why exactly are brains wrinkly? Is a wrinkly brain better than having a smooth brain? We’ll get to all of that. Wrinkly Brains One of the primary reasons smooth brain memes have become so popular is their humor and relatability. These memes poke fun at our collective desire to simplify complex ideas, highlighting how our brains can sometimes feel “too smooth” when faced with challenging concepts or situations. The ARX gene encodes for the aristaless related homeobox genes which are active in the early embryonic development to control formation of many tissues and structure. ARX is involved in the development of the embryonic forebrain, migration and communication of neurons as well as migration and proliferation of interneurons. [13] As ARX is expressed in the ganglionic eminences and the neocortical ventricular zone it can affect both radial and tangential migration. Similar to DCX, ARX is an X chromosome linked gene and is linked with other symptoms such as absence of portions of the brain, abnormal genitalia and severe epilepsy. [13] RELN [ edit ] In conclusion, the smooth brain meme is a fascinating phenomenon that speaks to our modern obsession with internet humor and cultural commentary. Whether you find it hilarious or disturbing, there’s no denying that this meme has captured our attention and sparked important conversations about ableism and mental health. Lissencephaly can cause a wide range of symptoms. It all depends on how severe the condition is and if it’s a part of a syndrome. Some children may develop as expected with a mild learning difference, while others may have many severe symptoms. The severity of symptoms can also vary widely.

Baker, Lisa. "Lissencephaly". The Resource Foundation for Children with Challenges. Archived from the original on 2 June 2013 . Retrieved 10 May 2013. Using this type of language as an insult can be seen as problematic because it perpetuates negative stereotypes about individuals who may have cognitive disabilities or otherwise think differently from what society views as “normal.” It’s important to consider how our words affect others around us and strive for more inclusive communication practices instead of harmful ones that tear down persons based on their level/type(s) intellectual ability/strengths & challenges faced throughout life either for having them (as signifiers/traits) being deemed desirable/negatives different contexts/circumstances. Conclusion Finally, when using the ‘Smooth Brain’ meme, make sure that you are not overusing it. While it can be an effective tool for injecting some levity into conversations and content, if you use it too much then it can become stale and lose its effectiveness. A good rule of thumb is to limit yourself to one instance per post or piece of content – otherwise you risk diluting its power and diminishing its impact on readers and viewers alike. A Reddit user from r/AskReddit joked, “‘What’s smoother than whipped cream and cannot solve basic arithmetic? A Smooth Brain.'” a b c Fong KW, Ghai S, Toi A, Blaser S, Winsor EJ, Chitayat D (December 2004). "Prenatal ultrasound findings of lissencephaly associated with Miller-Dieker syndrome and comparison with pre- and postnatal magnetic resonance imaging". Ultrasound in Obstetrics & Gynecology. 24 (7): 716–23. doi: 10.1002/uog.1777. PMID 15586369.Ghai S, Fong KW, Toi A, Chitayat D, Pantazi S, Blaser S (2006). "Prenatal US and MR imaging findings of lissencephaly: review of fetal cerebral sulcal development". Radiographics. 26 (2): 389–405. doi: 10.1148/rg.262055059. PMID 16549605. These factors cause impaired neuronal migration of the outer region of the brain during fetal development. Your cerebral cortex, the part of your brain that’s responsible for conscious movement and thought, normally has several deep gyri and sulci (grooves and folds). The genes associated with lissencephaly are still being discovered; however, due to advances in genetics individual genes are being identified as the cause of lissencephaly. [12] Mutations in LIS1, DCX ( doublecortin), ARX ( aristaless related homeobox), RELN have all been identified to cause lissencephaly. [13] Viral infections can also cause lissencephaly. [14] The ‘Smooth Brain’ meme can also be used to make light of everyday situations. For example, one image shows a person with an abnormally smooth head carrying several large bags of groceries. The caption reads, “Just trying to think ahead.” This joke pokes fun at the idea that people with smooth brains are always planning for the future.

Most children with lissencephaly need daily medications to prevent seizures and treat other complications. What is the life expectancy of a child with lissencephaly? Genetic causes of lissencephaly are due to genetic mutations. A genetic mutation is a change in a sequence of your DNA. Your DNA sequence gives your cells the information they need to perform their functions. If part of your DNA sequence isn’t complete or is damaged, you might experience symptoms of a genetic condition. The Smooth Brain Meme is a perfect example of how humor can influence our perceptions and attitudes toward certain issues. Spin-offs like “ Returning to Monke” highlight people longing for simpler times before modern technology and social conventions overtake our lives. Being able to participate in lighthearted banter about smooth brain jokes can enhance relationshipsby creating shared experiencesthat bring people closer together.Stupid as koalas are, it would be a shame to lose them to rampant climate change (no seriously Australia is on fire). If you’d like to donate to our friendly bear-fiends, here’s a link. However, it is important to note that the effects of interacting with these types of memes on individuals’ mental well-being are still debated within the scientific community. Memes As A Reflection Of Cultural Trends And Attitudes A Chinese family with an autosomal dominant inheritance pattern and a mutation in this gene has been reported. [16] DCX [ edit ]