a b World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. hdl: 10665/44053. ISBN 9789241547659. Certain medications (bile acid sequestrants such as cholestyramine/ colestipol, mineral oil, orlistat) can decrease the absorption of vitamin D. Take your doses of these medications as far as possible from your doses of vitamin D (at least 2 hours apart, longer if possible). It may be easiest to take vitamin D at bedtime if you are also taking these other medications. Ask your doctor or pharmacist how long you should wait between doses and for help finding a dosing schedule that will work with all your medications.

Vitamin D3 is essential for the absorption and utilization of calcium and phosphorus, which are vital for maintaining strong and healthy bones,” says Sam Schleiger, a functional medicine dietitian and founder of Simply Nourished, a nutrition practice in Elkhorn, Wisconsin. Researchers have reported that the compound is less toxic to non-target species than earlier generations of anticoagulant rodenticides ( Warfarin and congeners) or Bromethalin, [52] and that relay toxicosis (poisoning by eating a poisoned animal) has not been documented. [15] Nevertheless, the same source reports that use of cholecalciferol in rodenticides may still pose a significant hazard to other animals, such as dogs and cats, when rodenticide bait or other forms of cholecalciferol are directly ingested. [15] See also [ edit ] The EFSA reviewed safe levels of intake in 2012, [118] setting the tolerable upper limit for adults at 100 μg/day (4000 IU), a similar conclusion as the IOM.Cholecalciferol is also produced industrially for use in vitamin supplements from lichens, which is suitable for vegans. [42] [43] Stability [ edit ] The conversion from ergosterol to vitamin D 2 follows a similar procedure, forming previtamin D 2 by photolysis, which isomerizes to vitamin D 2 ( ergocalciferol). [172] The transformation of previtamin D 2 to vitamin D 2 in methanol has a rate comparable to that of a b Ross AC, Taylor CL, Yaktine AL, Del Valle HB, etal. (Institute of Medicine (US); Committee to Review Dietary Reference Intakes for Vitamin D and Calcium) (2011). Dietary Reference Intakes for Calcium and Vitamin D (PDF). doi: 10.17226/13050. ISBN 978-0-309-16394-1. PMID 21796828. S2CID 58721779. Many people are Vitamin D deficient—especially in the winter so moderate supplementation is probably a good idea. Before diving into the world of mega-dosing D3, be sure to speak with your physician first. Overdosing on a vitamin D supplement can be toxic and therefore detrimental to your health.

The Swedish National Food Agency recommends a daily intake of 10 μg (400 IU) of vitamin D 3 for children and adults up to 75 years, and 20 μg (800 IU) for adults 75 and older. [127] If you are taking the rapidly-dissolving tablets, dry your hands before handling the medication. Place each dose on the tongue, allow it to dissolve completely, and then swallow it with saliva or water. You do not need to take this medication with water. About Vitamin D". University of California, Riverside. November 2011. Archived from the original on 16 October 2017 . Retrieved 15 October 2017. Cholecalciferol is very sensitive to UV radiation and will rapidly, but reversibly, break down to form supra-sterols, which can further irreversibly convert to ergosterol. [ citation needed] Pesticide [ edit ]Dehydrocholesterol is the precursor of cholecalciferol. [2] Within the epidermal layer of skin, 7-dehydrocholesterol undergoes an electrocyclic reaction as a result of UVB light at wavelengths between 290 and 315nm, with peak synthesis occurring between 295 and 300nm. [38] This results in the opening of the vitamin precursor B-ring through a conrotatory pathway making previtamin D 3 (pre-cholecalciferol). [39] In a process which is independent of UV light, the pre-cholecalciferol then undergoes a [1,7] antarafacial sigmatropic rearrangement [40] and therein finally isomerizes to form vitamin D 3. If it is too difficult to incorporate the natural sources, then you can take a vitamin D3 supplement. A meta-analysis of 2007 concluded that daily intake of 1000 to 2000 IU per day of vitamin D 3 could reduce the incidence of colorectal cancer with minimal risk. [28] Also a 2008 study published in Cancer Research has shown the addition of vitamin D 3 (along with calcium) to the diet of some mice fed a regimen similar in nutritional content to a new Western diet with 1000 IU cholecalciferol per day prevented colon cancer development. [29] In humans, with 400 IU daily, there was no effect of cholecalciferol supplements on the risk of colorectal cancer. [30]

Remember that Vitamin D2 is found mainly in plants, while D3 comes mainly from animals. Mushrooms, especially when exposed to UV light, are a rich source of vitamin D, but it is mostly D2 with some D3. Like other vitamins, vitamin D is a substance needed for health but only in tiny amounts. Unlike other vitamins, it doesn't occur naturally in food but can be made in the body. Most people know that humans use sunlight to make vitamin D, the "sunshine vitamin." But modern humans don't get much sunlight, so we end up at the vitamin counter, often confused about what to buy. Getting enough vitamin D helps your body to lose fat while building muscle and strength. Studies have also found that those deficient in vitamin D may experience chronic muscle pain, achiness, and fatigue. 4) Diabetes Cholecalciferol is a form of vitamin D which is naturally synthesized in skin and functions as a pro-hormone, being converted to calcitriol. This is important for maintaining calcium levels and promoting bone health and development. [2] As a medication, cholecalciferol may be taken as a dietary supplement to prevent or to treat vitamin D deficiency. One gram is 40,000,000 (40x10 6) IU, equivalently 1 IU is 0.025μg or 25 ng. Dietary reference intake values for vitamin D (cholecalciferol and/or ergocalciferol) have been established and recommendations vary depending on the country:Cholecalciferol is produced industrially for use in vitamin supplements and to fortify foods. As a pharmaceutical drug it is called cholecalciferol ( USAN) or colecalciferol ( INN, BAN). It is produced by the ultraviolet irradiation of 7-dehydrocholesterol extracted from lanolin found in sheep's wool. [41] Cholesterol is extracted from wool grease and wool wax alcohols obtained from the cleaning of wool after shearing. The cholesterol undergoes a four-step process to make 7-dehydrocholesterol, the same compound that is produced in the skin of animals. The 7-dehydrocholesterol is then irradiated with ultraviolet light. Some unwanted isomers are formed during irradiation: these are removed by various techniques, leaving a resin which melts at about room temperature and usually has a potency of 25,000,000 to 30,000,000 International Units per gram. Cholecalciferol can be produced in skin from the light emitted by the UV lamps in tanning beds, which produce ultraviolet primarily in the UVA spectrum, but typically produce 4% to 10% of the total UV emissions as UVB. Levels in blood are higher in frequent users of tanning salons. [38]

van Groningen L, Opdenoordt S, van Sorge A, Telting D, Giesen A, de Boer H (April 2010). "Cholecalciferol loading dose guideline for vitamin D-deficient adults". European Journal of Endocrinology. 162 (4): 805–11. doi: 10.1530/EJE-09-0932. PMID 20139241.Vitamin D is one of the body’s most important vitamins, helping it with a variety of tasks: Vitamin D contributes to the normal function of the immune system and is very important for the body’s structural system, maintaining normal bone and muscle function. Vitamin D3 also contributes to the normal absorption and utilisation of calcium and phosphorus. The VDR regulates cell proliferation and differentiation. Vitamin D also affects the immune system, and VDRs are expressed in several white blood cells, including monocytes and activated T and B cells. [21] In vitro, vitamin D increases expression of the tyrosine hydroxylase gene in adrenal medullary cells, and affects the synthesis of neurotrophic factors, nitric oxide synthase, and glutathione. [22] Morgan D (2006). "Field efficacy of cholecalciferol gel baits for possum (Trichosurus vulpecula) control". New Zealand Journal of Zoology. 33 (3): 221–8. doi: 10.1080/03014223.2006.9518449. S2CID 83765759.