Expanded section on bilayer dynamics covers flippases, floppases, scramblases, and bilayer asymmetry New section, Chemical logic and common biochemical reactions, discusses common biochemical reaction types New medical box on how the high rate of glycolysis in cancerous tissue aids cancer diagnosis and treatment The 8th edition has been fully revised for up-to-date content, as well as to effectively support student study. Written for students learning biochemistry for the first time, the authors have identified and noted fundamental biochemistry principles throughout the text. Content has been streamlined so the text is focused on what is most important and useful to modern students and for future reference!

Updated discussion of the structure of the electron transfer complexes of mitochondria and chloroplasts, and of the Fo complex Problem Solving Video with diagrams, graphs and narration these videos walk students through problems on difficult topics helping them understand the right approach to the solution. Expanded and integrated treatment of local signaling circuits, including AKAPs and signaling complexes that include protein kinase A, adenylyl cyclase, and phosphodiesterase, and localized puffs and waves of Ca2+LearningCurve Adaptive Quizzing motivates reading and keeps students on pace with study with a fun game-like activity to quiz retention and understanding of concepts. The new edition brings this remarkable text into a new era. Like its predecessors, Lehninger Principles of Biochemistry, Sixth Edition strikes a careful balance of current science and enduring concepts, incorporating a tremendous amount of new findings, but only those that help illustrate biochemistry’s foundational principles. With this edition, students will encounter new information emerging from high throughput DNA sequencing, x-ray crystallography, and the manipulation of genes and gene expression, and other techniques. In addition, students will see how contemporary biochemistry has shifted away from exploring metabolic pathways in isolation to focusing on interactions among pathways. They will also get an updated understanding of the relevance of biochemistry to the study of human disease (especially diabetes) as well as the important role of evolutionary theory in biochemical research. New section on pharmaceuticals developed from an understanding of enzyme mechanism, using penicillin and HIV protease inhibitors as examples

Synthases and Synthetases; Ligases and Lyases; Kinases,Phosphatases, and Phosphorylases: Yes, the Names Are Confusing! An interactive e-book with embedded multimedia and features for highlighting, note-taking and accessibility support

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Mechanism Figures features step-by-step descriptions to help students understand the reaction process. Chemical Logic discusses the common biochemical reaction types that underlie all metabolic reactions, helping students to connect organic chemistry with biochemistry. Expanded coverage and updating of the biochemical connections between obesity, metabolic syndrome, and type 2 diabetes Strong on visualization including ‘Clear Art’ molecular structures created specifically for Lehninger to keep consistency with color and shape schemes, understandable figures which include numbers with annotated steps to explain complex processes, mechanism figures features step-by-step descriptions to help students understand the reaction process and summary figures to help students keep the big picture in mind while learning the specific.