Tempera, G., Corsello, S., Genovese, C., Caruso, F. E., and Nicolosi, D. Inhibitory activity of cranberry extract on the bacterial adhesiveness in the urine of women: an ex-vivo study. Int J Immunopathol.Pharmacol. 2010;23(2):611-618. View abstract. Mooren ES, Liefers WJ, de Leeuw JW. Cranberries after pelvic floor surgery for urinary tract infection prophylaxis: A randomized controlled trial. Neurourol Urodyn. 2020;39(5):1543-1549. View abstract. Fanos, V., Atzei, A., Zaffanello, M., Piras, A., and Cataldi, L. Cranberry and prevention of urinary tract infections in children. J Chemother. 2006;18 Spec no 3:21-24. View abstract. Ushijima K, Tsuruoka S, Tsuda H, Hasegawa G, Obi Y, Kaneda T, Takahashi M, Maekawa T, Sasaki T, Koshimizu TA, Fujimura A. Cranberry juice suppressed the diclofenac metabolism by human liver microsomes, but not in healthy human subjects. Br J Clin Pharmacol 2009;68(2):194-200. View abstract.

Jepson, R. G., Mihaljevic, L., and Craig, J. Cranberries for preventing urinary tract infections. Cochrane.Database.Syst.Rev. 2000;(2):CD001321. View abstract.Bodet, C., Chandad, F., and Grenier, D. Inhibition of host extracellular matrix destructive enzyme production and activity by a high-molecular-weight cranberry fraction. J Periodontal Res 2007;42(2):159-168. View abstract. Wang SY, Jiao H. Scavenging capacity of berry crops on superoxide radicals, hydrogen peroxide, hydroxyl radicals, and singlet oxygen. J Agric Food Chem 2000;48:5677-84.. View abstract. Better blood sugar control: Several studies have found that cranberry juice can significantly reduce blood sugar levels in people with diabetes ( 32, 33, 34). Mergenhagen KA, Sherman O. Elevated International Normalized Ratio after concurrent ingestion of cranberry sauce and warfarin. Am J Health-Syst Pharm 2008;65:2113-6. View abstract.

Cranberries ( Vaccinium macrocarpon) are particularly rich in (poly)phenols such as anthocyanins, proanthocyanidins (both A- and B-type), flavonols and hydroxycinnamic acids ( 35), and are recognised for their antioxidant and anti-inflammatory effects ( 36– 38) along with their capacity to modulate cardiometabolic endpoints ( 38– 40). However, limited information is currently available regarding the evaluation of cranberries on cognitive performance, with the only previous study exploring the impact of cranberry intake on cognitive performance reporting no cognitive benefit of a cranberry juice consumption for 6 weeks in older adults with normal cognitive functions ( 41). We know in general that eating enough non-starchy vegetables and getting enough fruits in your diet reduces your risk of certain cancers,” says O’Neill. Are cranberries healthy?These mixed conclusions could be due to differences in study design or because cranberry may not be as effective at preventing the 25–35% of UTIs caused by fungi or bacteria other than E. coli ( 13, 14, 15, 16). Summary Sun, J. and Hai, Liu R. Cranberry phytochemical extracts induce cell cycle arrest and apoptosis in human MCF-7 breast cancer cells. Cancer Lett 9-8-2006;241(1):124-134. View abstract. In fact, cranberries are among the richest fruit sources of proanthocyanidins — especially the A-type ( 14, 20). Ferrara, P., Romaniello, L., Vitelli, O., Gatto, A., Serva, M., and Cataldi, L. Cranberry juice for the prevention of recurrent urinary tract infections: a randomized controlled trial in children. Scand.J Urol.Nephrol. 2009;43(5):369-372. View abstract.

Stapleton, A. E., Dziura, J., Hooton, T. M., Cox, M. E., Yarova-Yarovaya, Y., Chen, S., and Gupta, K. Recurrent urinary tract infection and urinary Escherichia coli in women ingesting cranberry juice daily: a randomized controlled trial. Mayo.Clin.Proc. 2012;87(2):143-150. View abstract.Valentova, K., Stejskal, D., Bednar, P., Vostalova, J., Cihalik, C., Vecerova, R., Koukalova, D., Kolar, M., Reichenbach, R., Sknouril, L., Ulrichova, J., and Simanek, V. Biosafety, antioxidant status, and metabolites in urine after consumption of dried cranberry juice in healthy women: a pilot double-blind placebo-controlled trial. J Agric Food Chem 4-18-2007;55(8):3217-3224. View abstract. If you suspect that you have a UTI, talk to your healthcare professional. The primary course of treatment should be antibiotics.

Masnadi Shirazi K, Shirinpour E, Masnadi Shirazi A, Nikniaz Z. Effect of cranberry supplementation on liver enzymes and cardiometabolic risk factors in patients with NAFLD: a randomized clinical trial. BMC Complement Med Ther 2021;21(1):283. View abstract. Cranberries are also high in salicylic acid, a naturally occurring anti-inflammatory compound ( 48, 49). But fresh cranberries tend to be sour and are rarely eaten raw. You’ll mostly see cranberries in juice form, but cranberry juice also tends to include added sugars. A-type proanthocyanidins. Also called condensed tannins, these polyphenols are believed to be effective against UTIs ( 8, 13, 14). Hormoznejad R, Mohammad Shahi M, Rahim F, Helli B, Alavinejad P, Sharhani A. Combined cranberry supplementation and weight loss diet in non-alcoholic fatty liver disease: a double-blind placebo-controlled randomized clinical trial. Int J Food Sci Nutr. 2020:1-10. View abstract.McMurdo MET, Argo I, Phillips G, et al. Cranberry or trimethoprim for the prevention of recurrently urinary tract infections? A randomized controlled trial in older women. J Antimicrob Chemother 2009;63:389-95. View abstract. Reid, G., Hsiehl, J., Potter, P., Mighton, J., Lam, D., Warren, D., and Stephenson, J. Cranberry juice consumption may reduce biofilms on uroepithelial cells: pilot study in spinal cord injured patients. Spinal Cord. 2001;39(1):26-30. View abstract.