Per esaminare in che modo la lattoferrina possa influire sulle ossa, è stata utilizzata in forma arricchita con ribonucleasi. Singh PK, Schaefer AL, Parsek MR, Moninger TO, Welsh MJ, Greenberg EP (October 2000). "Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms". Nature. 407 (6805): 762–4. Bibcode: 2000Natur.407..762S. doi: 10.1038/35037627. PMID 11048725. S2CID 4372096. Chang R, Ng TB, Sun WZ (September 2020). "Lactoferrin as potential preventative and adjunct treatment for COVID-19". International Journal of Antimicrobial Agents. 56 (3): 106118. doi: 10.1016/j.ijantimicag.2020.106118. PMC 7390755. PMID 32738305.

Non è quindi un caso che la lattoferrina venga sfruttata anche dall'industria alimentare per trattare le carcasse di manzo e proteggerle dalla contaminazione batterica di superficie. a b Giansanti F, Rossi P, Massucci MT, Botti D, Antonini G, Valenti P, Seganti L (2002). "Antiviral activity of ovotransferrin discloses an evolutionary strategy for the defensive activities of lactoferrin". Biochemistry and Cell Biology. 80 (1): 125–130. doi: 10.1139/o01-208. PMID 11908636. Despite the sudden peak in the related studies in the literature in the last 3 years due to the pandemic, Lf still hasn't gotten the attention it deserves in the COVID-19 studies. Although the main focus of COVID-19 studies is on the prevention with vaccines, the effect of Lf on the immune system to prevent COVID-19 and the synergistic studies with vaccines are almost non-existent. The previous studies on Lf mainly focus on the treatment potential of Lf. On the other hand, despite the early studies on Lf effects on COVID-19 studies not only put forth promising results but also showed comparable or even better results than traditional treatment strategies such as SOC, there are still not enough studies on the treatment potential of this multifunctional protein. Meveol: orphan drug status granted by the FDA for the treatment of cystic fibrosis". United States Food and Drug Administration. 2009-11-05. Archived from the original on 2009-12-24 . Retrieved 2010-01-23. When administered into the vagina: There isn't enough reliable information to know if lactoferrin is safe or what the side effects might be. Pregnancy: Lactoferrin is commonly consumed in foods. Lactoferrin is possibly safe when taken by mouth in doses of 200 mg daily during pregnancy. There isn't enough reliable information to know if lactoferrin vaginal tablets are safe to use when pregnant. Stay on the safe side and avoid use.Lactoferrin supplements reduce the risk of respiratory tract infections, based on a recent meta-analysis of randomized controlled trials. [9] As with any supplements sold online, quality may be an issue because nutritional supplement production quality controls are not subject to the same strict regulatory process as medicines. [10] History [ edit ]

E' parte fondamentale dei globuli bianchi neutrofili, ma si crede essere prodotta anche da altre cellule. Di Mario F, Aragona G, Bo ND, et al. Use of lactoferrin for Helicobacter pylori eradication. Preliminary results. J Clin Gastroenterol 2003;36:396-8. View abstract.

Lactoferrin ( LF), also known as lactotransferrin ( LTF), is a multifunctional protein of the transferrin family. Lactoferrin is a globular glycoprotein with a molecular mass of about 80 kDa that is widely represented in various secretory fluids, such as milk, saliva, tears, and nasal secretions. Lactoferrin is also present in secondary granules of PMNs and is secreted by some acinar cells. Lactoferrin can be purified from milk or produced recombinantly. Human colostrum ( "first milk") has the highest concentration, followed by human milk, then cow milk (150mg/L). [5] Più abbondante nel colostro rispetto al latte di transizione e di mantenimento, la lattoferrina risulta inoltre tipica dei granulociti neutrofili, cellule immunitarie con funzioni di difesa da infezioni batteriche e fungine. Ali AS, Hasan SS, Kow CS, Merchant HA (October 2021). "Lactoferrin reduces the risk of respiratory tract infections: A meta-analysis of randomized controlled trials" (PDF). Clinical Nutrition ESPEN. 45: 26–32. doi: 10.1016/j.clnesp.2021.08.019. PMID 34620326. S2CID 238475090. Birgens HS (April 1985). "Lactoferrin in plasma measured by an ELISA technique: evidence that plasma lactoferrin is an indicator of neutrophil turnover and bone marrow activity in acute leukaemia". Scandinavian Journal of Haematology. 34 (4): 326–31. doi: 10.1111/j.1600-0609.1985.tb00757.x. PMID 3858982.